Servagi-Vernat S, Ali D, Roubieu C, Durdux C, Laccourreye O, Giraud P
Service d'Oncologie Radiothérapie, Centre Hospitalier Universitaire, boulevard Fleming, 25000 Besançon cedex, France.
Université Paris Descartes, Paris Sorbonne Cité, Service d'Oncologie Radiothérapie, Hôpital européen Georges-Pompidou, 20, rue Leblanc, 75015 Paris, France.
Eur Ann Otorhinolaryngol Head Neck Dis. 2015 Feb;132(1):25-9. doi: 10.1016/j.anorl.2013.09.006. Epub 2014 Jun 9.
Adjuvant radiotherapy after surgery or exclusive radiotherapy, with or without concurrent chemotherapy is a valuable treatment option in the great majority of patients with head and neck cancer. Recent technical progress in radiotherapy has resulted in a decreased incidence of xerostomia. Another common toxicity of radiotherapy is dysphagia, which alters the nutritional status and quality of life of patients in remission. The objective of this review is to describe the physiology of swallowing function, the pathophysiology of radiation-induced dysphagia and the various strategies currently available to prevent this complication.
手术后辅助放疗或单纯放疗,联合或不联合同步化疗,是绝大多数头颈癌患者的一种有价值的治疗选择。放疗技术的最新进展已导致口干症发病率降低。放疗的另一种常见毒性是吞咽困难,这会改变缓解期患者的营养状况和生活质量。本综述的目的是描述吞咽功能的生理学、放射性吞咽困难的病理生理学以及目前可用于预防这种并发症的各种策略。