重新审视肥大细胞在皮肤伤口愈合及博来霉素诱导的皮肤纤维化中的潜在作用。
Rethinking the potential roles of mast cells in skin wound healing and bleomycin-induced skin fibrosis.
作者信息
Galli Stephen J
机构信息
Department of Pathology, Stanford University School of Medicine, Stanford, California, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA.
出版信息
J Invest Dermatol. 2014 Jul;134(7):1802-1804. doi: 10.1038/jid.2014.142.
Skin wound healing and bleomycin-induced skin fibrosis are thought to reflect complex interactions among diverse cell types. Several lines of evidence have implicated mast cells in these tissue responses. However, data from Willenborg et al. (this issue) and from three other groups suggest that, in at least these examples of cutaneous tissue remodeling, mast cells may not have nonredundant roles.
皮肤伤口愈合和博来霉素诱导的皮肤纤维化被认为反映了多种细胞类型之间的复杂相互作用。有几条证据表明肥大细胞参与了这些组织反应。然而，Willenborg等人（本期）以及其他三个研究小组的数据表明，至少在这些皮肤组织重塑的例子中，肥大细胞可能并不具有不可替代的作用。
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