胰腺癌的早期检测：需要什么才能诊断和治疗可治愈的胰腺肿瘤？
The early detection of pancreatic cancer: what will it take to diagnose and treat curable pancreatic neoplasia?
机构信息
Authors' Affiliations: Departments of Medicine; Surgery;
Surgery; Pathology; Oncology;
出版信息
Cancer Res. 2014 Jul 1;74(13):3381-9. doi: 10.1158/0008-5472.CAN-14-0734. Epub 2014 Jun 12.
Abstract
Pancreatic cancer is the deadliest of all solid malignancies. Early detection offers the best hope for a cure, but characteristics of this disease, such as the lack of early clinical symptoms, make the early detection difficult. Recent genetic mapping of the molecular evolution of pancreatic cancer suggests that a large window of opportunity exists for the early detection of pancreatic neoplasia, and developments in cancer genetics offer new, potentially highly specific approaches for screening of curable pancreatic neoplasia. We review the challenges of screening for early pancreatic neoplasia, as well as opportunities presented by incorporating molecular genetics into these efforts.
摘要
胰腺癌是所有实体恶性肿瘤中最致命的一种。早期发现是治愈的最佳希望，但该疾病的特征，如缺乏早期临床症状，使得早期检测变得困难。最近对胰腺癌分子进化的遗传图谱分析表明，早期检测胰腺肿瘤存在很大的机会窗口，癌症遗传学的发展为可治愈的胰腺肿瘤的筛查提供了新的、潜在的高度特异性方法。我们回顾了筛查早期胰腺肿瘤的挑战，以及将分子遗传学纳入这些努力所带来的机遇。
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