Mrówczyński Radosław, Bunge Alexander, Liebscher Jürgen
Department of Chemistry, Humboldt-University Berlin, Brook-Taylor-Str. 2, 12489 Berlin (Germany); National Institute of Research and Development for Isotopic and Molecular Technologies (INCDTIM), Str. Donath 65-103, RO-400293 Cluj-Napoca (Romania).
Chemistry. 2014 Jul 7;20(28):8647-53. doi: 10.1002/chem.201402532. Epub 2014 Jun 12.
Polydopamine (PDA) is easily available by oxidation of dopamine and is widely used for persistent coatings of various materials. It is hitherto considered to be inert in many interesting biomedical and other applications. Results presented here, reveal an unexpected behavior of polydopamine as an organocatalyst in direct aldol reactions under mild conditions. Evidence was found for dual catalysis making use of amino and phenolic hydroxy groups found in PDA. Thus scientists must be aware that PDA is not an innocent polymer and can cause unwanted side effects in important applications, such as in biomedicine or as supports in catalysis.
聚多巴胺（PDA）可通过多巴胺氧化轻松获得，广泛用于各种材料的持久涂层。迄今为止，在许多有趣的生物医学和其他应用中，它被认为是惰性的。此处给出的结果揭示了聚多巴胺在温和条件下直接羟醛反应中作为有机催化剂的意外行为。发现了利用PDA中存在的氨基和酚羟基进行双重催化的证据。因此，科学家必须意识到PDA并非无害聚合物，在重要应用中，如生物医学或催化载体中，可能会引起不良副作用。
