Wang Wen-juan, Pui Margaret H, Guo Yan, Hu Xiao-shu, Wang Huan-jun, Yang Dong
Department of Radiology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; Department of Radiology, Weifang People's Hospital, Weifang, Shandong, China.
J Magn Reson Imaging. 2014 Nov;40(5):1099-102. doi: 10.1002/jmri.24450. Epub 2013 Oct 29.
To assess the feasibility of diffusion tensor imaging (DTI) of normal kidneys and the influence of hydration state.
Ten healthy volunteers underwent renal DTI after fasting for 12 hours and 4 hours, without fasting, and following water diuresis. Medullary and cortical apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values were measured and compared in the four different states of hydration. DTI was performed with a 3T magnetic resonance imaging (MRI) system using fat-saturated single-shot spin-echo echo planar imaging sequence.
ADC of normal cortex (2.387 ± 0.081 × 10(-3) mm(2) /s) was significantly higher (t = 20.126, P = 0) than that of medulla (1.990 ± 0.063 × 10(-3) mm(2) /s). The FA value of normal cortex (0.282 ± 0.017) was significantly lower (t = -42.713, P = 0) than that of medulla (0.447 ± 0.022). The ADC and FA values of the left renal cortex (2.404 ± 0.082 × 10(-3) mm(2) /s, 0.282 ± 0.017) and medulla (2.002 ± 0.081 × 10(-3) mm(2) /s, 0.452 ± 0.024) were not significantly different (P > 0.05) from those of right renal cortex (2.369 ± 0.080 × 10(-3) mm(2) /s, 0.283 ± 0.018) and medulla (1.978 ± 0.039 × 10(-3) mm(2) /s, 0.443 ± 0.019). Values for ADC (×10(-3) mm(2) /s) and FA in the 12-hour fasting, 4-hour fasting, nonfasting, and water diuresis states were 2.372 ± 0.095 and 0.278 ± 0.018, 2.387 ± 0.081 and 0.282 ± 0.017, 2.416 ± 0.051 and 0.279 ± 0.023, 2.421 ± 0.068, and 0.270 ± 0.021, respectively, in cortex, 1.972 ± 0.084 and 0.438 ± 0.014, 1.990 ± 0.063 and 0.447 ± 0.022, 2.021 ± 0.081 and 0.450 ± 0.031, 2.016 ± 0.076 and 0.449 ± 0.028, respectively, in medulla. The ADC and FA values in different hydration states were not significantly different (P > 0.05).
DTI of normal kidneys is feasible with reproducible ADC and FA values independent of hydration states.
评估正常肾脏扩散张量成像（DTI）的可行性及水化状态的影响。
10名健康志愿者在禁食12小时、禁食4小时、不禁食以及水利尿后接受肾脏DTI检查。在四种不同水化状态下测量并比较髓质和皮质的表观扩散系数（ADC）及各向异性分数（FA）值。使用3T磁共振成像（MRI）系统，采用脂肪饱和单次激发自旋回波平面成像序列进行DTI检查。
正常皮质的ADC（2.387±0.081×10⁻³mm²/s）显著高于髓质（1.990±0.063×10⁻³mm²/s）（t = 20.126，P = 0）。正常皮质的FA值（0.282±0.017）显著低于髓质（0.447±0.022）（t = -42.713，P = 0）。左肾皮质（2.404±0.082×10⁻³mm²/s，0.282±0.017）和髓质（2.002±0.081×10⁻³mm²/s，0.452±0.024）的ADC和FA值与右肾皮质（2.369±0.080×10⁻³mm²/s，0.283±0.018）和髓质（1.978±0.039×10⁻³mm²/s，0.443±0.019）相比，差异无统计学意义（P＞0.05）。皮质在禁食12小时、禁食4小时、不禁食和水利尿状态下的ADC（×10⁻³mm²/s）和FA值分别为2.372±0.095和0.278±0.018、2.387±0.081和0.282±0.017、2.416±0.051和0.279±0.023、2.421±0.068和0.270±0.021；髓质的相应值分别为1.972±0.084和0.438±0.014、1.990±0.063和0.447±0.022、2.021±0.081和0.450±0.031、2.016±0.076和0.449±0.028。不同水化状态下的ADC和FA值差异无统计学意义（P＞0.05）。
正常肾脏的DTI是可行的，其ADC和FA值具有可重复性，且不受水化状态影响。
