Liu Liwen, Tuo Shengjun, Zhang Jianlei, Zuo Lei, Liu Fang, Hao Lili, Sun Yandan, Yang Liping, Shao Hong, Qi Wei, Zhou Xiaodong, Ge Shuping
Department of Ultrasound, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China.
Department of Ultrasound, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China ; Department of Ultrasound, Yan'an People's Hospital, Yan'an, Shaanxi 716000, P.R. China.
Exp Ther Med. 2014 Jun;7(6):1457-1464. doi: 10.3892/etm.2014.1617. Epub 2014 Mar 12.
The early detection of abnormal left ventricular systolic functions in patients with hypertrophic cardiomyopathy (HCM) remains a challenge. The aim of this study was to identify a novel method for the assessment of left ventricular systolic function in patients with HCM. A total of 65 patients with HCM were included in this study. The patients were divided into obstructive HCM (HOCM; 16 cases) and non-obstructive HCM (NOHCM; 49 cases) groups. The healthy control group comprised 48 participants. Two-dimensional (2D) speckle-tracking technology was used to measure the left ventricular global and segmental longitudinal strains and mitral annular displacement (MADs). Compared with healthy control group, the six segmental strains and the global strain of the left ventricle (LS) increased while six segmental MADs and MAD of the mitral annulus decreased in the HOCM and NOHCM groups (P<0.05). In addition, the six segmental MADs of the mitral annulus were significantly negatively correlated with the six segmental strains of the left ventricle (r=-0.744 to -0.647, P<0.001). MAD was significantly negatively correlated with LS (r=-0.857, P<0.001). The tissue motion annular displacement (TMAD) at the midpoint was significantly negatively correlated with LS (r=-0.871, P<0.001). The 2D TMAD technique of measuring MAD was feasible and practically approachable for rapidly evaluating the left ventricular longitudinal global and segmental systolic functions of patients with HCM.
肥厚型心肌病（HCM）患者左心室收缩功能异常的早期检测仍然是一项挑战。本研究的目的是确定一种评估HCM患者左心室收缩功能的新方法。本研究共纳入65例HCM患者。这些患者被分为梗阻性HCM（HOCM；16例）和非梗阻性HCM（NOHCM；49例）组。健康对照组包括48名参与者。采用二维（2D）斑点追踪技术测量左心室整体和节段纵向应变以及二尖瓣环位移（MADs）。与健康对照组相比，HOCM组和NOHCM组左心室的六个节段应变和整体应变（LS）增加，而二尖瓣环的六个节段MADs和MAD降低（P<0.05）。此外，二尖瓣环的六个节段MADs与左心室的六个节段应变显著负相关（r=-0.744至-0.647，P<0.001）。MAD与LS显著负相关（r=-0.857，P<0.001）。中点处的组织运动环位移（TMAD）与LS显著负相关（r=-0.871，P<0.001）。测量MAD的二维TMAD技术对于快速评估HCM患者左心室纵向整体和节段收缩功能是可行且切实可行的。
