甲基强的松龙与氨基胍联合应用对大鼠脊髓损伤后功能恢复的影响。
Effects of the combination of methylprednisolone with aminoguanidine on functional recovery in rats following spinal cord injury.
作者信息
Li Zongshu, DU Juan, Sun Hongxia, Mang Jing, He Jinting, Wang Jiaoqi, Liu Hongyu, Xu Zhongxin
机构信息
Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China ; Department of Neurology, Jilin Province People's Hospital, Changchun, Jilin 130021, P.R. China.
Department of Rheumatology and Immunology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China.
出版信息
Exp Ther Med. 2014 Jun;7(6):1605-1610. doi: 10.3892/etm.2014.1613. Epub 2014 Mar 10.
Methylprednisolone (MP), a synthetic glucocorticoid, has been widely used as a standard therapeutic agent for the treatment of spinal cord injury (SCI). The combination of MP and other pharmacological agents aimed at enhancing functional recovery is desirable as the beneficial effects of MP are controversial, due to a variety of side-effects. Aminoguanidine (AG), a small water-soluble compound, is potentially useful in the treatment of acute SCI. The aim of the present study was to determine the effects of MP and AG, administered in combination, following SCI in adult rats. In rats with SCI, the combination therapy group treated with AG (75 mg/kg) and MP (0.75 mg/kg) exhibited significantly reduced levels of cytokine expression and cell apoptosis compared with those in the control group. In addition, the data demonstrated that the combination therapy significantly enhanced the recovery of limb function. These data clearly suggest that treatment with a combination of MP and AG represents a promising strategy of clinically applicable pharmacological therapy for the rapid initiation of neuroprotection following SCI.
甲泼尼龙（MP）是一种合成糖皮质激素，已被广泛用作治疗脊髓损伤（SCI）的标准治疗药物。由于MP存在多种副作用，其有益效果存在争议，因此将MP与其他旨在促进功能恢复的药物联合使用是可取的。氨基胍（AG）是一种水溶性小分子化合物，在急性SCI治疗中可能有用。本研究的目的是确定成年大鼠SCI后联合使用MP和AG的效果。在SCI大鼠中，与对照组相比，接受AG（75 mg/kg）和MP（0.75 mg/kg）联合治疗的联合治疗组细胞因子表达水平和细胞凋亡显著降低。此外，数据表明联合治疗显著促进了肢体功能的恢复。这些数据清楚地表明，MP和AG联合治疗是一种有前景的临床适用药物治疗策略，可在SCI后迅速启动神经保护作用。
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