Mony P K, Rose D P, Sreedaran P, D'Souza G, Srinivasan K
Division of Epidemiology, St John's Research Institute, Bangalore, India.
Indian J Med Res. 2014 Apr;139(4):523-30.
BACKGROUND & OBJECTIVES: Nicotine dependence is a widely prevalent and harmful chronic addictive disorder. Quitting tobacco use is however, uncommon in India. We present long-term treatment outcomes of out-patient, tobacco cessation treatments from a specialty clinic setting in southern India.
Patients seen in a tobacco cessation clinic were characterized for tobacco use, nicotine dependence and motivation for quitting and offered pharmacologic/non-pharmacologic treatment. They were subsequently contacted telephonically at a mean (±standard deviation) of 24 (±9.1) months to assess tobacco cessation outcome defined as 'point prevalence of 1-month abstinence' by self-reporting.
The mean age of participants was 48.0 ±14.0 yr. Tobacco use distribution was: beedis only (22%), cigarettes only (49%), beedis and cigarettes (18%), chewing only (2%), and smoking and chewing (9%). Two-thirds had high level of nicotine dependence. Of the 189 patients enrolled, only 15 per cent attended follow up clinics. Only 106 (56%) patients were successfully contacted telephonically and 83 (44%) were lost to follow up. Self-reported point prevalence abstinence was 5 per cent by 'intent-to-treat' analysis and 10 per cent by 'responder' analysis. Two clinical parameters - high level of nicotine dependence [estimated by the heaviness of smoking index (HSI)] and the absence of vascular or other chronic disease were found to be associated with successful quitting; these were however, not significant on multivariate analysis.
INTERPRETATION & CONCLUSIONS: Our study has identified low quit-rates in a cohort of patients attending a hospital-based tobacco cessation clinic. In the absence of clear-cut predictors of cessation with low quit-rates, there should be continued efforts to improve cessation outcomes and identify predictors for action.
尼古丁依赖是一种广泛流行且有害的慢性成瘾性疾病。然而在印度,戒烟并不常见。我们展示了印度南部一家专科诊所门诊戒烟治疗的长期效果。
在戒烟诊所就诊的患者被评估烟草使用情况、尼古丁依赖程度和戒烟动机,并接受药物/非药物治疗。随后通过电话联系他们,平均(±标准差)在24(±9.1)个月时评估戒烟结果,通过自我报告定义为“1个月戒烟的时点患病率”。
参与者的平均年龄为48.0±14.0岁。烟草使用分布情况为:仅抽比迪烟(22%)、仅抽香烟(49%)、比迪烟和香烟都抽(18%)、仅咀嚼烟草(2%)以及既抽烟又咀嚼烟草(9%)。三分之二的人有高度尼古丁依赖。在189名登记患者中,只有15%的人到后续诊所就诊。仅106名(56%)患者通过电话成功联系上,83名(44%)失访。通过“意向性分析”自我报告的时点患病率戒烟率为5%,通过“应答者分析”为10%。发现两个临床参数——高度尼古丁依赖[通过吸烟量指数(HSI)评估]以及无血管或其他慢性病与成功戒烟有关;然而,在多变量分析中这些并不显著。
我们的研究发现,在一家医院戒烟诊所的患者队列中戒烟率较低。在缺乏明确的戒烟预测因素且戒烟率较低的情况下,应持续努力改善戒烟效果并确定可采取行动的预测因素。