Gerber M A, Randolph M F, DeMeo K, Feder H M, Kaplan E L
Department of Pediatrics, University of Connecticut School of Medicine, Farmington.
Am J Dis Child. 1989 Feb;143(2):153-5. doi: 10.1001/archpedi.1989.02150140039016.
To determine if a single daily dose of penicillin V would be effective in the treatment of group A beta-hemolytic streptococcal (GABHS) pharyngitis, 154 patients with GABHS pharyngitis were randomly assigned to receive 750 mg of penicillin V once daily for ten days or 250 mg of penicillin V three times daily for ten days. The two regimens were comparable in their ability to eradicate GABHS from the upper respiratory tract in 18 to 24 hours and in their impact on the clinical course of the disease. However, a bacteriologic treatment failure occurred in six (8%) of the 76 patients in the three-times-daily group and in 16 (22%) of the 74 patients in the once-daily group. These findings support the current recommendation that penicillin V be given in two or more divided doses for a full ten days for the treatment of GABHS pharyngitis.
为确定每日单次剂量的青霉素V是否能有效治疗A组β溶血性链球菌（GABHS）咽炎，154例GABHS咽炎患者被随机分配，一组接受每日一次750毫克青霉素V，共十天；另一组接受每日三次250毫克青霉素V，共十天。这两种治疗方案在18至24小时内从呼吸道清除GABHS的能力以及对疾病临床进程的影响方面具有可比性。然而，每日三次组的76例患者中有6例（8%）出现细菌学治疗失败，每日一次组的74例患者中有16例（22%）出现细菌学治疗失败。这些发现支持目前的建议，即治疗GABHS咽炎时，青霉素V应分两次或更多次给药，持续十天。
