Gerber M A, Randolph M F, Chanatry J, Wright L L, De Meo K, Kaplan E L
Am J Dis Child. 1987 Feb;141(2):224-7. doi: 10.1001/archpedi.1987.04460020114043.
To determine the effectiveness of a short (five-day) course of penicillin V potassium therapy, 172 patients with group A beta-hemolytic streptococcal (GABHS) pharyngitis were randomly assigned to receive 250 mg of penicillin V potassium three times daily for either five or ten days. The patients in the two treatment groups were comparable with respect to clinical findings, compliance, and serologic response to GABHS. A bacteriologic treatment failure was defined as the presence of the same serotype of GABHS in the follow-up as in the initial throat culture and occurred in 13 (18%) of the 73 patients in the five-day treatment group and in six (6%) of the 99 patients in the ten-day treatment group. These findings support the current recommendation for a full ten days of oral penicillin V therapy for the treatment of GABHS pharyngitis.
为确定短期（五天）青霉素V钾治疗方案的有效性，172例A组β溶血性链球菌（GABHS）咽炎患者被随机分配，分别接受每日三次、每次250mg青霉素V钾的治疗，疗程为五天或十天。两个治疗组的患者在临床表现、依从性以及对GABHS的血清学反应方面具有可比性。细菌学治疗失败定义为随访时GABHS血清型与初始咽拭子培养结果相同，五天治疗组的73例患者中有13例（18%）出现治疗失败，十天治疗组的99例患者中有6例（6%）出现治疗失败。这些研究结果支持目前关于采用全疗程十天口服青霉素V治疗GABHS咽炎的建议。
