Gerber M A, Spadaccini L J, Wright L L, Deutsch L, Kaplan E L
Am J Dis Child. 1985 Nov;139(11):1145-8. doi: 10.1001/archpedi.1985.02140130083035.
An investigation was performed to compare the effectiveness of oral penicillin V given twice daily with penicillin V given three times daily in the treatment of group A beta-hemolytic streptococcal (GABHS) pharyngitis. Patients were randomly assigned to receive 250 mg of penicillin V either two or three times daily for ten days. Overall, 23 (23%) of 99 patients had the same strain of GABHS isolated from their follow-up as from their initial throat culture and were considered to have bacteriologic-treatment failures. Of the 50 patients in the three-times-daily group, nine (18%) had bacteriologic-treatment failures, while 14 (28.5%) of 49 patients in the twice-daily group had bacteriologic-treatment failures. The results of this and earlier investigations suggest that penicillin V given twice daily is as effective as penicillin V given three times daily for the treatment of GABHS pharyngitis.
开展了一项研究，以比较每日两次口服青霉素V与每日三次口服青霉素V治疗A组β溶血性链球菌（GABHS）咽炎的疗效。患者被随机分配，接受每日两次或三次、每次250mg青霉素V的治疗，疗程为十天。总体而言，99名患者中有23名（23%）在随访时分离出的GABHS菌株与其初始咽拭子培养结果相同，被视为细菌学治疗失败。在每日三次服药组的50名患者中，有9名（18%）细菌学治疗失败，而在每日两次服药组的49名患者中，有14名（28.5%）细菌学治疗失败。本次及早期研究结果表明每日两次服用青霉素V治疗GABHS咽炎的疗效与每日三次服用青霉素V相当。
