Genovese Salvatore, Fiorito Serena, Locatelli Marcello, Carlucci Giuseppe, Epifano Francesco
Dipartimento di Farmacia, Università "G. d'Annunzio" Chieti-Pescara, Via dei Vestini 31, 66100, Chieti Scalo, (CH), Italy,
Plant Foods Hum Nutr. 2014 Sep;69(3):255-60. doi: 10.1007/s11130-014-0427-8.
4'-Geranyloxyferulic (GOFA) and boropinic acid have been discovered during the last decade as interesting phytochemicals having valuable pharmacological effects as cancer chemopreventive, anti-inflammatory, neuroprotective, and anti-Helicobacter pylori agents. A reverse-phase HPLC-UV/Vis method for the separation and quantification of the title oxyprenylated ferulic acid derivatives in extracts obtained from peels of nine edible Citrus and Fortunella fruits was successfully applied. Concentration values showed a great variation between the different species, being orange (C. sinensis) the fruit richest in GOFA (0.141 ± 0.011 mg/g of exocarp fresh weight) and kumquat (Fortunella japonica) the one in which boropinic acid was recorded as the most abundant phytochemical (0.206 ± 0.002 mg/g of exocarp fresh weight). Both secondary metabolites were not detected only in three species. The set-up methodology showed limits of quantification (LOQ) values, that were able to selectively quantify both GOFA and boropinic acid. Results described herein depict a potential chemopreventive dietary feeding role for the Rutaceae spp. under investigation.
在过去十年中，4'-香叶氧基阿魏酸（GOFA）和硼酸已被发现是有趣的植物化学物质，具有作为癌症化学预防剂、抗炎剂、神经保护剂和抗幽门螺杆菌剂的宝贵药理作用。一种反相高效液相色谱-紫外/可见分光光度法成功应用于从九种可食用柑橘和金橘果实的果皮中提取的提取物中标题氧化异戊烯基阿魏酸衍生物的分离和定量。浓度值在不同物种之间显示出很大差异，橙子（甜橙）是GOFA含量最高的水果（外果皮鲜重0.141±0.011毫克/克），金橘（日本金橘）是硼酸含量最丰富的植物化学物质（外果皮鲜重0.206±0.002毫克/克）。仅在三个物种中未检测到这两种次生代谢物。所建立的方法显示了定量限（LOQ）值，能够选择性地定量GOFA和硼酸。本文所述结果描述了所研究的芸香科植物在化学预防饮食喂养方面的潜在作用。
