Chao Owen Y, Wang An-Li, Nikolaus Susanne, de Souza Silva Maria A
Center for Behavioral Neuroscience, University of Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany.
Center for Behavioral Neuroscience, University of Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany.
Behav Brain Res. 2015 May 15;285:208-12. doi: 10.1016/j.bbr.2014.06.006. Epub 2014 Jun 11.
Animals treated with unilateral 6-hydroxydopamine (6-ODHA) injections, an animal model of Parkinson's disease, exhibit deficits in memory for temporal order, but show intact novel object recognition. Since senktide, a potent neurokinin-3 receptor (NK3-R) agonist, has been shown to have promnestic effects in the aged rat and to alleviate scopolamine-induced impairment, the present study aimed to assess possible promnestic effects of senktide in the hemiparkinsonian rat model. Animals received unilateral 6-ODHA microinjections into the medial forebrain bundle. Two weeks later, they were randomly assigned to treatment with vehicle, 0.2, or 0.4 mg/kg senktide. Temporal order memory and place recognition tests were conducted, locomotor activity and turning behavior were assessed in the open field and anxiety-related behavior was measured in the light-dark box. Treatments were administered 30 min prior to behavioral testing with an interval of seven days between tests. The animals treated with 0.2 mg/kg senktide exhibited temporal order memory, unlike the vehicle-treated group. No significant treatment effects were found in the open field and light-dark box. Administration of 0.2 mg/kg senktide may influence the prefrontal cortex and hippocampus, leading to compensations for deficits in memory for temporal order.
用单侧6-羟基多巴胺（6-ODHA）注射处理的动物，即帕金森病的动物模型，在时间顺序记忆方面表现出缺陷，但新物体识别能力完好。由于强效神经激肽-3受体（NK3-R）激动剂senktide已被证明在老年大鼠中具有促记忆作用，并能减轻东莨菪碱诱导的损伤，因此本研究旨在评估senktide在半帕金森病大鼠模型中可能的促记忆作用。动物接受单侧6-ODHA微量注射到内侧前脑束。两周后，它们被随机分配接受载体、0.2或0.4mg/kg senktide治疗。进行了时间顺序记忆和位置识别测试，在旷场中评估运动活动和转向行为，并在明暗箱中测量与焦虑相关的行为。在行为测试前30分钟给药，测试之间间隔七天。与载体处理组不同，用0.2mg/kg senktide处理的动物表现出时间顺序记忆。在旷场和明暗箱中未发现显著的治疗效果。给予0.2mg/kg senktide可能会影响前额叶皮层和海马体，从而补偿时间顺序记忆的缺陷。
