Chen Yan-Zhi, Fan Zeng-Hui, Zhao Yu-Xia, Bai Lu, Zhou Bao-Shen, Zhang Hai-Bo, Liu Dan
Department of Radiation Oncology, The Fourth Affiliated Hospital of China Medical University, Chongshan East Street No. 4, Yuhong District, Shenyang, 110032, People's Republic of China.
Tumour Biol. 2014 Sep;35(9):9229-32. doi: 10.1007/s13277-014-2199-z. Epub 2014 Jun 16.
To investigate the association of LIG1 with the risk of lung cancer, all subjects of unrelated ethnic Han Chinese in Liaoning Province were involved in a hospital-based case-control study. The case group consisted of 370 histologically diagnosed lung cancer patients; 314 controls were selected from cancer-free patients during Dec. 2009 to Dec. 2011. LIG1 rs1050298SNP were analyzed by TaqMan real-time PCR method. All statistical analyses were performed with Statistical Product and Service Solution sv13.0 (SPSS). The genotype distribution frequency of LIG1 rs1050298 SNP displayed significant difference between the case and the control group. Individuals carrying the LIG1 rs1050298 T genotype had higher risks of lung cancer, especially those with squamous cell carcinoma.
为了研究LIG1与肺癌风险的关联，辽宁省所有无血缘关系的汉族受试者参与了一项基于医院的病例对照研究。病例组由370例经组织学诊断的肺癌患者组成；对照组从2009年12月至2011年12月期间的无癌患者中选取314例。采用TaqMan实时荧光定量PCR法分析LIG1 rs1050298单核苷酸多态性（SNP）。所有统计分析均使用统计产品与服务解决方案软件v13.0（SPSS）进行。LIG1 rs1050298 SNP的基因型分布频率在病例组和对照组之间存在显著差异。携带LIG1 rs1050298 T基因型的个体患肺癌的风险更高，尤其是鳞状细胞癌患者。
