放射损伤早期快速诊断指标的研究是癌症患者放疗期间最重要的。
Study of Indicators for Early and Rapid Diagnosis of Radiation Injury Is the Most Important in Patients With Cancer During Radiotherapy.
作者信息
Liu Gang, Niu Li-Mei, Wang Li-Qin, Li Ye, Wu Xiao-Qin, Liu Yin-Yin, Zhang Rong
机构信息
Gansu Provincial Center for Disease Control and Prevention, Lanzhou, Gansu, China.
出版信息
Dose Response. 2020 Mar 30;18(1):1559325820913360. doi: 10.1177/1559325820913360. eCollection 2020 Jan-Mar.
OBJECTIVE
To establish a complete technical solution for the radiation biological dose estimation, to enable prediction of individuals' response to radiotherapy (RT), and to control treatment dose for reduced irradiation injury and promote repair; and to evaluate the risk of radiation-induced late effects for patients undergoing external photon beam RT and provide the reliable dose-response relationships.
METHODS
Select 49 tumor patients using Co and linear accelerator for radiation therapy; initial radiation dose was 250 cGy. Chromosome aberration and blood count were analyzed before radiation therapy and 2 hours after the first day of RT.
RESULTS
Two hours after the first day of RT, peripheral blood cell count of lymphocytes of patients with cancer was significantly decreased ( < .01). The frequency of chromosome aberration was higher ( < .01).
CONCLUSION
High-dose radiation of the radiation therapy makes significant injuries to peripheral blood lymphocytes.
目的
建立完整的辐射生物剂量估算技术方案，以预测个体对放射治疗（RT）的反应，控制治疗剂量以减少辐射损伤并促进修复；评估接受外照射光子束放疗患者发生辐射诱发晚期效应的风险，并提供可靠的剂量反应关系。
方法
选择49例使用钴和直线加速器进行放射治疗的肿瘤患者；初始放射剂量为250厘戈瑞。在放疗前及放疗第一天后2小时分析染色体畸变和血细胞计数。
结果
放疗第一天后2小时，癌症患者淋巴细胞外周血细胞计数显著下降（P<0.01）。染色体畸变频率更高（P<0.01）。
结论
放射治疗的高剂量辐射对外周血淋巴细胞造成显著损伤。
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