淋病奈瑟菌对吞噬细胞和非吞噬细胞的最大黏附需要能量。
Energy is required for maximal adherence of Neisseria gonorrhoeae to phagocytic and nonphagocytic cells.
作者信息
Weber R D, Britigan B E, Svendsen T, Cohen M S
机构信息
Department of Medicine, University of North Carolina, Chapel Hill 27599-7030.
出版信息
Infect Immun. 1989 Mar;57(3):785-90. doi: 10.1128/iai.57.3.785-790.1989.
Abstract
The possibility that gonococcal energy might play a role in the interaction of Neisseria gonorrhoeae with both phagocytic and nonphagocytic cells was examined. Respiratory chain inhibitors including KCN and amobarbital resulted in reduction in gonococcal association with human neutrophils. Similar results were seen with HeLa cells and the human promyelocytic (HL-60) cell line. Identical conditions did not affect the opsonin-dependent association of Staphylococcus aureus with the same cell types. New protein synthesis by gonococci did not account for the observed reduction in association. These results suggest that energy is needed for maximal opsonin-independent association of gonococci with mammalian cells.
摘要
研究了淋球菌能量在淋病奈瑟菌与吞噬细胞和非吞噬细胞相互作用中可能发挥的作用。包括氰化钾和异戊巴比妥在内的呼吸链抑制剂导致淋球菌与人类中性粒细胞的结合减少。在人宫颈癌细胞（HeLa细胞）和人早幼粒细胞（HL-60）细胞系中也观察到了类似结果。相同条件下，并不影响金黄色葡萄球菌与相同细胞类型的调理素依赖性结合。淋球菌新合成的蛋白质并不能解释观察到的结合减少现象。这些结果表明，淋球菌与哺乳动物细胞的最大程度非调理素依赖性结合需要能量。
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