Department of Biological and Environmental Sciences, Faculty of Natural Sciences, Walter Sisulu University, PBX1, Mthatha 5117, South Africa.
Unit for Environmental Sciences and Management, Faculty of Natural and Agricultural Sciences, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa.
Molecules. 2021 Apr 28;26(9):2557. doi: 10.3390/molecules26092557.
(L.) N.E.Br. (Mesembryanthemaceae), commonly known as kanna or kougoed, is an effective indigenous medicinal plant in South Africa, specifically to the native San and Khoikhoi tribes. Today, the plant has gained strong global attraction and reputation due to its capabilities to promote a sense of well-being by relieving stress with calming effects. Historically, the plant was used by native San hunter-gatherers and Khoi people to quench their thirst, fight fatigue and for healing, social, and spiritual purposes. Various studies have revealed that extracts of the plant have numerous biological properties and isolated alkaloids of are currently being used as dietary supplements for medicinal purposes and food. Furthermore, current research has focused on the commercialization of the plant because of its treatment in clinical anxiety and depression, psychological and psychiatric disorders, improving mood, promoting relaxation and happiness. In addition, several studies have focused on the isolation and characterization of various beneficial bioactive compounds including alkaloids from the plant. Sceletium was reviewed more than a decade ago and new evidence has been published since 2008, substantiating an update on this South African botanical asset. Thus, this review provides an extensive overview of the biological and pharmaceutical properties of as well as the bioactive compounds with an emphasis on antimicrobial, anti-inflammatory, anti-oxidant, antidepressant, anxiolytic, and other significant biological effects. There is a need to critically evaluate the bioactivities and responsible bioactive compounds, which might assist in reinforcing and confirming the significant role of kanna in the promotion of healthy well-being in these stressful times.
（L.）N.E.Br.（马齿苋科），通常被称为卡纳或古古德，是南非一种有效的本土药用植物，特别是对当地的桑人和科伊桑部落。如今，由于其具有缓解压力、产生镇静作用、促进幸福感的能力，这种植物在全球范围内引起了强烈的关注和声誉。历史上，当地的桑族狩猎采集者和科伊人用这种植物解渴、消除疲劳、治疗疾病、进行社交和精神活动。多项研究表明，该植物的提取物具有多种生物特性，其分离出的生物碱目前被用作药用和食品的膳食补充剂。此外，由于其在治疗临床焦虑和抑郁、心理和精神障碍、改善情绪、促进放松和幸福感方面的应用，目前的研究重点是该植物的商业化。此外，多项研究集中于从该植物中分离和表征各种有益的生物活性化合物，包括生物碱。十多年前曾对塞勒图姆进行过综述，自 2008 年以来发表了新的证据，为这一南非植物资产的更新提供了依据。因此，本综述提供了对 生物学和药物特性以及生物活性化合物的广泛概述，重点介绍了抗菌、抗炎、抗氧化、抗抑郁、抗焦虑和其他重要的生物学作用。需要批判性地评估生物活性和相关的生物活性化合物，这可能有助于加强和确认卡纳在促进健康幸福方面的重要作用，尤其是在这个充满压力的时代。
