线粒体蛋白质稳态对衰老和寿命的调控
Mitochondrial proteostasis in the control of aging and longevity.
作者信息
Jensen Martin Borch, Jasper Heinrich
机构信息
Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945-1400, USA.
Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945-1400, USA.
出版信息
Cell Metab. 2014 Aug 5;20(2):214-25. doi: 10.1016/j.cmet.2014.05.006. Epub 2014 Jun 12.
Abstract
Mitochondria play a central role in the aging process. Studies in model organisms have started to integrate mitochondrial effects on aging with the maintenance of protein homeostasis. These findings center on the mitochondrial unfolded protein response (UPR(mt)), which has been implicated in lifespan extension in worms, flies, and mice, suggesting a conserved role in the long-term maintenance of cellular homeostasis. Here, we review current knowledge of the UPR(mt) and discuss its integration with cellular pathways known to regulate lifespan. We highlight how insight into the UPR(mt) is revolutionizing our understanding of mitochondrial lifespan extension and of the aging process.
摘要
线粒体在衰老过程中起着核心作用。对模式生物的研究已开始将线粒体对衰老的影响与蛋白质稳态的维持联系起来。这些发现集中在线粒体未折叠蛋白反应（UPR(mt)）上，该反应与线虫、果蝇和小鼠的寿命延长有关，表明其在细胞稳态的长期维持中具有保守作用。在此，我们综述了关于UPR(mt)的现有知识，并讨论了它与已知调节寿命的细胞通路的整合情况。我们强调了对UPR(mt)的深入了解如何正在彻底改变我们对线粒体寿命延长和衰老过程的理解。
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