动脉内卒中治疗的影像生物标志物
Imaging Biomarkers for Intra-arterial Stroke Therapy.
作者信息
Berkhemer Olvert A, Kamalian Shervin, González R Gilberto, Majoie Charles B L M, Yoo Albert J
机构信息
Division of Diagnostic and Interventional Neuroradiology, Department of Imaging, Massachusetts General Hospital, 55 Fruit Street GRB 241, Boston, MA 02114, USA ; Harvard Medical School, Boston, MA, USA ; Department of Radiology, Academic Medical Center Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Division of Diagnostic and Interventional Neuroradiology, Department of Imaging, Massachusetts General Hospital, 55 Fruit Street GRB 241, Boston, MA 02114, USA ; Harvard Medical School, Boston, MA, USA.
出版信息
Cardiovasc Eng Technol. 2013 Dec 1;4(4):339-351. doi: 10.1007/s13239-013-0148-4.
Despite high rates of early revascularization with intra-arterial stroke therapy, the clinical efficacy of this approach has not been clearly demonstrated. Neuroimaging biomarkers will be useful in future trials for patient selection and for outcomes evaluation. To identify patients who are likely to benefit from intra-arterial therapy, the combination of vessel imaging, infarct size quantification and degree of neurologic deficit appears critical. Perfusion imaging may be useful in specific circumstances, but requires further validation. For measuring treatment outcomes, surrogate biomarkers that appear suitable are angiographic reperfusion as measured by the modified Thrombolysis in Cerebral Infarction scale and final infarct volume.
尽管动脉内卒中治疗的早期血管再通率很高，但这种方法的临床疗效尚未得到明确证实。神经影像学生物标志物将有助于未来试验中的患者选择和疗效评估。为了识别可能从动脉内治疗中获益的患者，血管成像、梗死灶大小量化和神经功能缺损程度的联合应用显得至关重要。灌注成像在特定情况下可能有用，但需要进一步验证。对于测量治疗效果，合适的替代生物标志物是改良脑梗死溶栓量表测量的血管造影再通和最终梗死体积。
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