Corbel T, Gayrard V, Puel S, Lacroix M Z, Berrebi A, Gil S, Viguié C, Toutain P-L, Picard-Hagen N
INRA, UMR 1331 Toxalim, Research in Food Toxicology, F-31027 Toulouse, France; Université de Toulouse, INPT, ENVT, EIP, UPS, F-31076 Toulouse, France.
Hôpital Paule de Viguier, Service de Gynécologie Obstétrique, CHU Toulouse, F-31059 Toulouse, France.
Reprod Toxicol. 2014 Aug;47:51-8. doi: 10.1016/j.reprotox.2014.06.001. Epub 2014 Jun 14.
The widespread human exposure to Bisphenol A (BPA), an endocrine disruptor interfering with developmental processes, raises the question of the risk for human health of BPA fetal exposure. In humans, highly variable BPA concentrations have been reported in the feto-placental compartment. However the human fetal exposure to BPA still remains unclear. The aim of the study was to characterize placental exchanges of BPA and its main metabolite, Bisphenol A-Glucuronide (BPA-G) using the non-recirculating dual human placental perfusion. This high placental bidirectional permeability to the lipid soluble BPA strongly suggests a transport by passive diffusion in both materno-to-fetal and feto-to-maternal direction, leading to a calculated ratio between fetal and maternal free BPA concentrations of about 1. In contrast, BPA-G has limited placental permeability, particularly in the materno-to-fetal direction. Thus the fetal exposure to BPA conjugates could be explained mainly by its limited capacity to extrude BPA-G.
双酚A（BPA）作为一种干扰发育过程的内分泌干扰物，在人群中广泛存在，这引发了胎儿暴露于BPA对人类健康风险的问题。在人类中，胎儿-胎盘组织中BPA浓度的变化很大。然而，人类胎儿对BPA的暴露情况仍不清楚。本研究的目的是利用非循环双胎盘灌注法来表征BPA及其主要代谢物双酚A-葡萄糖醛酸苷（BPA-G）的胎盘交换情况。胎盘对脂溶性BPA具有较高的双向通透性，这强烈表明其在母胎和胎母方向均通过被动扩散进行转运，由此计算得出胎儿与母体游离BPA浓度之比约为1。相比之下，BPA-G的胎盘通透性有限，尤其是在母胎方向。因此，胎儿对BPA结合物的暴露主要可归因于其排出BPA-G的能力有限。
