Safina D D, Abdulkhakov R A, Abdulkhakov S R, Odintsova A Kh, Cheremina N A
Eksp Klin Gastroenterol. 2013(12):92-6.
Extraintestinal manifestations of inflammatory bowel diseases (IBD) are common in both ulcerative colitis and Crohn's disease. Dermatological manifestations have been reported in one-third of all extraintestinal manifestations of IBD. Erythema nodosum and pyoderma gangrenosum are the most frequently described in the literature. There is no data on the development of alopecia as a cutaneous manifestation of IBD in most of studies. A clinical case of combination of ulcerative colitis and alopecia in young woman is presented in the article. There are several possible causes of alopecia in patients with IBD, such as nutritional deficiencies, side effects of medications or autoimmune alopecia. Most often there is no correlation between the severity of clinical bowel manifestations and other organs involvement, and response to therapy. So the combination of alopecia with IBD, in particular ulcerative colitis, confirms the importance of autoimmune mechanisms in genesis of these diseases.
炎症性肠病（IBD）的肠外表现常见于溃疡性结肠炎和克罗恩病。在IBD所有肠外表现中，有三分之一报告有皮肤表现。文献中最常描述的是结节性红斑和坏疽性脓皮病。在大多数研究中，尚无关于脱发作为IBD皮肤表现发生情况的数据。本文介绍了一名年轻女性溃疡性结肠炎合并脱发的临床病例。IBD患者脱发有几种可能原因，如营养缺乏、药物副作用或自身免疫性脱发。临床肠道表现的严重程度与其他器官受累及治疗反应之间通常无相关性。因此，脱发与IBD尤其是溃疡性结肠炎的合并出现证实了自身免疫机制在这些疾病发生中的重要性。
