Hoyos M, Sarrión J V, Pérez-Castellanos T, Prieto M, Marty M L, Garrigues V, Berenguer J
Department of Internal Medicine, Hospital La Fe, Valencia, Spain.
Hepatology. 1989 Mar;9(3):449-51. doi: 10.1002/hep.1840090318.
The relationship between donor status for antibody to hepatitis B core antigen and the occurrence of non-A, non-B posttransfusion hepatitis in the recipient was prospectively studied in 112 patients undergoing open-heart surgery who were followed for 6.5 months after surgery. Non-A, non-B posttransfusion hepatitis occurred in five (7.93%) of 63 patients who had received at least one anti-HBc-positive blood unit compared to seven (14.28%) of 49 patients who received anti-HBc-negative blood only. Statistical analysis revealed that the incidence of non-A, non-B posttransfusion hepatitis was independent of the use of blood positive for anti-HBc. Based upon these results and the high prevalence (17.3%) of anti-HBc among our blood donor population, the exclusion of anti-HBc-positive blood does not seem appropriate to achieve a reduction in the incidence of non-A, non-B posttransfusion hepatitis.
对112例接受心脏直视手术的患者进行了前瞻性研究，观察乙肝核心抗原抗体供血者状态与受血者非甲非乙型输血后肝炎发生之间的关系，术后随访6.5个月。63例接受过至少一个抗-HBc阳性血液单位的患者中有5例（7.93%）发生了非甲非乙型输血后肝炎，而仅接受抗-HBc阴性血液的49例患者中有7例（14.28%）发生了该疾病。统计分析显示，非甲非乙型输血后肝炎的发生率与使用抗-HBc阳性血液无关。基于这些结果以及我们供血人群中抗-HBc的高流行率（17.3%），排除抗-HBc阳性血液似乎并不适合降低非甲非乙型输血后肝炎的发生率。
