Ahmad Mohammad Zaki, Akhter Shabib, Mohsin Nehal, Abdel-Wahab Basel A, Ahmad Javed, Warsi Musarrat Husain, Rahman Mahfoozur, Mallick Neha, Ahmad Farhan Jalees
Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, Saudi Arabia.
Curr Drug Discov Technol. 2014;11(3):197-213. doi: 10.2174/1570163811666140616153436.
Curcumin (CUR) is a yellow-coloured polyphenolic compound obtained from the rhizomes of Curcuma longa. In-depth pharmacological screening of curcumin has given the evidence that CUR persuades shielding and curative effects against various cancers, cardiovascular, wound healing effect and neuro disorders etc owning to anti-oxidant, antiproliferative, anti-inflammatory, anti-angiogenic and antimicrobial activities. However, miserable bioavailability due to poor aqueous solubility limits the application of CUR in various ailments. Different methodologies including the nanoparticle technology have been reported for the bioavailability enhancement of CUR. Nanoparticles exhibit not only the improvement in the solubility of CUR and alike lipophilic molecules (resulted in improved bioavailability) but also giving the opportunity for the disease specific cellular and organ targeting. Improved bioavailability and disease based site specific delivery of CUR is more likely to bring it as a safe multifunctional medicine.
姜黄素（CUR）是一种从姜黄根茎中提取的黄色多酚化合物。对姜黄素进行的深入药理学筛选表明，由于其具有抗氧化、抗增殖、抗炎、抗血管生成和抗菌活性，姜黄素对各种癌症、心血管疾病具有保护和治疗作用，还具有伤口愈合作用以及对神经疾病等的作用。然而，姜黄素由于水溶性差导致生物利用度极低，限制了其在各种疾病中的应用。已经报道了包括纳米颗粒技术在内的不同方法来提高姜黄素的生物利用度。纳米颗粒不仅能提高姜黄素及类似亲脂性分子的溶解度（从而提高生物利用度），还为疾病特异性的细胞和器官靶向提供了机会。提高姜黄素的生物利用度以及基于疾病的位点特异性递送更有可能使其成为一种安全的多功能药物。
