糖尿病会增加早期胃癌发展的风险。

Diabetes mellitus increases the risk of early gastric cancer development.

机构信息

Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka, Japan.

Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.

出版信息

Eur J Cancer. 2014 Aug;50(12):2065-71. doi: 10.1016/j.ejca.2014.05.020. Epub 2014 Jun 13.

DOI:10.1016/j.ejca.2014.05.020

PMID:24934410

Abstract

BACKGROUND

The significance of diabetes mellitus (DM) in gastric carcinogenesis still remains unclear. We investigated whether DM would be a risk factor for the development of early gastric cancer.

METHODS

Factors related to the presence of gastric cancer were examined in patients undergoing medical health checkups. We then investigated whether DM was related to the development of early gastric cancer during an endoscopic follow-up study.

RESULTS

Gastric cancer was detected in 14 (1.0%) of 1463 patients at the first endoscopic examination and was significantly associated with the severity of gastric atrophy and the presence of DM. During the follow-up period (range 36-108 months; mean 70.0 months), early gastric cancer was newly detected in 26 (1.8%) of the 1449 patients in whom gastric cancer had not been detected at the first examination. Gastric cancer was detected in 17 (1.3%) of 1301 patients without DM, and in 9 (6.1%) of 148 patients with DM (P < 0.0001). Multivariate analyses demonstrated that open-type gastric atrophy and DM were independently related to the development of early gastric cancer (P < 0.0001 and P = 0.020, respectively). Gastric cancer was identified in 14 (5.1%) of 274 patients who had open-type atrophic gastritis without DM, whereas it was identified in 8 (16.0%) of 50 patients who had both open-type atrophic gastritis and DM (P = 0.0042).

CONCLUSION

DM increases the risk of early gastric cancer development.

摘要

背景

糖尿病（DM）在胃癌发生中的意义仍不清楚。我们研究了 DM 是否是早期胃癌发展的危险因素。

方法

在接受健康体检的患者中检查与胃癌存在相关的因素。然后，我们在一项内镜随访研究中调查了 DM 是否与早期胃癌的发展有关。

结果

在首次内镜检查中，1463 例患者中发现了 14 例（1.0%）胃癌，并且胃癌与胃萎缩的严重程度和 DM 的存在显著相关。在随访期间（范围 36-108 个月；平均 70.0 个月），在首次检查未发现胃癌的 1449 例患者中，新发现了 26 例（1.8%）早期胃癌。在 1301 例无 DM 的患者中发现了 17 例（1.3%）胃癌，在 148 例有 DM 的患者中发现了 9 例（6.1%）（P <0.0001）。多变量分析表明，开放式胃萎缩和 DM 与早期胃癌的发展独立相关（P <0.0001 和 P =0.020）。在无 DM 的 274 例开放式萎缩性胃炎患者中，有 14 例（5.1%）发现了胃癌，而在同时患有开放式萎缩性胃炎和 DM 的 50 例患者中，有 8 例（16.0%）发现了胃癌（P =0.0042）。