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用于癌症治疗的医学中的荧光碳纳米颗粒。

Fluorescent carbon nanoparticles in medicine for cancer therapy.

作者信息

Kumar Vinit, Toffoli Giuseppe, Rizzolio Flavio

机构信息

Department of Translational Research National Cancer Institute-CRO , Via Franco Gallini 2, Aviano 33081, Italy.

出版信息

ACS Med Chem Lett. 2013 Oct 24;4(11):1012-3. doi: 10.1021/ml400394a. eCollection 2013 Nov 14.

DOI:10.1021/ml400394a
PMID:24936239
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4056989/
Abstract

Nanotechnology provides exciting opportunities for the development of novel, clinically relevant diagnostic and therapeutic multifunctional systems. Fluorescent carbon nanoparticles (CNPs) due to their intrinsic fluorescence and high biocompatibility are among the best candidates. As innovative nanomaterials, CNPs could be utilized both as nontoxic drug delivery system and bioimaging. We foresee a great future for CNPs in cancer diagnostic and therapy.

摘要

纳米技术为新型临床相关诊断和治疗多功能系统的开发提供了令人兴奋的机遇。荧光碳纳米颗粒(CNPs)因其固有的荧光特性和高生物相容性,是最佳候选材料之一。作为创新的纳米材料,CNPs既可以用作无毒药物递送系统,也可以用于生物成像。我们预见CNPs在癌症诊断和治疗方面有着广阔的前景。

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本文引用的文献

1
In vivo imaging of tumour bearing near-infrared fluorescence-emitting carbon nanodots derived from tire soot.基于轮胎炭黑的近红外荧光纳米碳点的荷瘤动物体内成像。
Chem Commun (Camb). 2013 Nov 11;49(87):10290-2. doi: 10.1039/c3cc45215h.
2
Functional surface engineering of C-dots for fluorescent biosensing and in vivo bioimaging.用于荧光生物传感和体内生物成像的 C 点功能表面工程。
Acc Chem Res. 2014 Jan 21;47(1):20-30. doi: 10.1021/ar400023s. Epub 2013 Aug 2.
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Carbon nanoparticle-based fluorescent bioimaging probes.基于碳纳米粒子的荧光生物成像探针。
Sci Rep. 2013;3:1473. doi: 10.1038/srep01473.
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The golden age: gold nanoparticles for biomedicine.黄金时代:金纳米颗粒在生物医学中的应用
Chem Soc Rev. 2012 Apr 7;41(7):2740-79. doi: 10.1039/c1cs15237h. Epub 2011 Nov 22.
5
Toxicity and cellular uptake of gold nanoparticles: what we have learned so far?金纳米颗粒的毒性与细胞摄取:我们目前了解到了什么?
J Nanopart Res. 2010 Sep;12(7):2313-2333. doi: 10.1007/s11051-010-9911-8. Epub 2010 Apr 6.
6
Luminescent carbon nanodots: emergent nanolights.发光碳纳米点:新兴的纳米光源。
Angew Chem Int Ed Engl. 2010 Sep 10;49(38):6726-44. doi: 10.1002/anie.200906623.
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Bandgap-like strong fluorescence in functionalized carbon nanoparticles.功能化碳纳米颗粒中类似带隙的强荧光。
Angew Chem Int Ed Engl. 2010 Jul 19;49(31):5310-4. doi: 10.1002/anie.201000982.
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Carbon Dots as Nontoxic and High-Performance Fluorescence Imaging Agents.碳点作为无毒且高性能的荧光成像剂
J Phys Chem C Nanomater Interfaces. 2009 Sep 28;113(42):18110-18114. doi: 10.1021/jp9085969.
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Fluorescent carbon nanoparticles derived from candle soot.源自蜡烛烟灰的荧光碳纳米颗粒。
Angew Chem Int Ed Engl. 2007;46(34):6473-5. doi: 10.1002/anie.200701271.
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Fluorescence quenching of dye molecules near gold nanoparticles: radiative and nonradiative effects.金纳米颗粒附近染料分子的荧光猝灭:辐射和非辐射效应。
Phys Rev Lett. 2002 Nov 11;89(20):203002. doi: 10.1103/PhysRevLett.89.203002. Epub 2002 Oct 24.