Ugron Adám, Szikora István, Paál György
Interv Med Appl Sci. 2014 Jun;6(2):61-8. doi: 10.1556/IMAS.6.2014.2.2. Epub 2014 Jun 4.
Flow diverters (FDs) have been successfully applied in the recent decade to the treatment of intracranial aneurysms by impairing the communication between the flows in the parent artery and the aneurysm and, thus, the blood within the aneurysm sac. It would be desirable to have a simple and accurate computational method to follow the changes in the peri- and intraaneurysmal flow caused by the presence of FDs. The detailed flow simulation around the intricate wire structure of the FDs has three disadvantages: need for high amount of computational resources and highly skilled professionals to prepare the computational grid, and also the lack of validation that makes the invested effort questionable. In this paper, we propose a porous layer method to model the hydraulic resistance (HR) of one or several layers of the FDs. The basis of this proposal is twofold: first, from an application point of view, the only interesting parameter regarding the function of the FD is its HR; second, we have developed a method to measure the HR with a simple apparatus. We present the results of these measurements and demonstrate their utility in numerical simulations of patient-specific aneurysm simulations.
近十年来,血流导向装置(FDs)已成功应用于颅内动脉瘤的治疗,通过削弱载瘤动脉与动脉瘤内血流之间的连通性,进而减少瘤腔内的血流。若能有一个简单且准确的计算方法来跟踪由血流导向装置的存在所引起的瘤周和瘤内血流变化,那将是很理想的。在血流导向装置复杂的金属丝结构周围进行详细的血流模拟存在三个缺点:需要大量的计算资源以及需要高技能的专业人员来准备计算网格,并且缺乏验证,这使得所投入的努力是否值得存疑。在本文中,我们提出一种多孔层方法来模拟一层或多层血流导向装置的水力阻力(HR)。该提议基于两点:其一,从应用角度来看,关于血流导向装置功能的唯一有趣参数就是其水力阻力;其二,我们已开发出一种用简单设备测量水力阻力的方法。我们展示了这些测量结果,并证明了它们在特定患者动脉瘤模拟数值模拟中的效用。