Latgé Jean-Paul, Beauvais Anne
Unité des Aspergillus, Institut Pasteur, Paris, France.
Unité des Aspergillus, Institut Pasteur, Paris, France.
Curr Opin Microbiol. 2014 Aug;20:111-7. doi: 10.1016/j.mib.2014.05.009. Epub 2014 Jun 14.
The polysaccharide cell wall is the extracellular armour of the fungal cell. Although essential in the protection of the fungal cell against aggressive external stresses, the biosynthesis of the polysaccharide core is poorly understood. For a long time it was considered that this cell wall skeleton was a fixed structure whose role was only to be sensed as non-self by the host and consequently trigger the defence response. It is now known that the cell wall polysaccharide composition and localization continuously change to adapt to their environment and that these modifications help the fungus to escape from the immune system. Moreover, cell wall polysaccharides could function as true virulence factors.
多糖细胞壁是真菌细胞的细胞外防护层。尽管多糖核心的生物合成对于保护真菌细胞免受外界侵袭性压力至关重要，但其机制却鲜为人知。长期以来，人们认为这种细胞壁骨架是一种固定结构，其作用仅仅是被宿主识别为非自身物质从而触发防御反应。现在我们知道，细胞壁多糖的组成和定位会不断变化以适应环境，这些修饰有助于真菌逃避免疫系统。此外，细胞壁多糖可能是真正的致病因子。
