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Associations between dietary acrylamide intake and plasma sex hormone levels.膳食丙烯酰胺摄入与血浆性激素水平的关系。
Cancer Epidemiol Biomarkers Prev. 2013 Nov;22(11):2024-36. doi: 10.1158/1055-9965.EPI-13-0509. Epub 2013 Aug 27.
3
Dietary intake of acrylamide and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.膳食丙烯酰胺摄入量与欧洲癌症与营养前瞻性调查（EPIC）队列人群胰腺癌风险的关系。
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Eur J Cancer. 2013 Apr;49(6):1374-403. doi: 10.1016/j.ejca.2012.12.027. Epub 2013 Feb 26.
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Trends in endometrial cancer incidence by race and histology with a correction for the prevalence of hysterectomy, SEER 1992 to 2008.按种族和组织学分类的子宫内膜癌发病率趋势，校正了子宫切除术的流行率，SEER 1992 至 2008 年。
Cancer Epidemiol Biomarkers Prev. 2013 Feb;22(2):233-41. doi: 10.1158/1055-9965.EPI-12-0996. Epub 2012 Dec 12.
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Dietary acrylamide intake of adults in the European Prospective Investigation into Cancer and Nutrition differs greatly according to geographical region.欧洲癌症与营养前瞻性调查研究（EPIC）表明，成年人的膳食丙烯酰胺摄入量因地域差异而有很大不同。
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Challenges in estimating the validity of dietary acrylamide measurements.估算膳食丙烯酰胺测量值有效性的挑战。
Eur J Nutr. 2013 Aug;52(5):1503-12. doi: 10.1007/s00394-012-0457-7. Epub 2012 Nov 1.
9
A prospective study on dietary acrylamide intake and the risk for breast, endometrial, and ovarian cancers.一项关于饮食丙烯酰胺摄入与乳腺癌、子宫内膜癌和卵巢癌风险的前瞻性研究。
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Hormonal contraception and risk of cancer.激素避孕与癌症风险。
Hum Reprod Update. 2010 Nov-Dec;16(6):631-50. doi: 10.1093/humupd/dmq022. Epub 2010 Jun 12.

饮食中丙烯酰胺与欧洲癌症与营养前瞻性调查队列中子宫内膜癌风险的关系。

Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.

机构信息

Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Avda Gran Via Barcelona 199-203, 08908L'Hospitalet de Llobregat, Barcelona, Spain.

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, Heidelberg 69120, Germany.

出版信息

Br J Cancer. 2014 Aug 26;111(5):987-97. doi: 10.1038/bjc.2014.328. Epub 2014 Jun 17.

DOI:10.1038/bjc.2014.328
PMID:24937665
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4150262/
Abstract

BACKGROUND

Three prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The objective of this study was to evaluate the association between acrylamide intake and EC risk: for overall EC, for type-I EC, and in never smokers and never users of oral contraceptives (OCs). Smoking is a source of acrylamide, and OC use is a protective factor for EC risk.

METHODS

Cox regression was used to estimate hazard ratios (HRs) for the association between acrylamide intake and EC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Acrylamide intake was estimated from the EU acrylamide monitoring database, which was matched with EPIC questionnaire-based food consumption data. Acrylamide intake was energy adjusted using the residual method.

RESULTS

No associations were observed between acrylamide intake and overall EC (n=1382) or type-I EC risk (n=627). We observed increasing relative risks for type-I EC with increasing acrylamide intake among women who both never smoked and were non-users of OCs (HRQ5vsQ1: 1.97, 95% CI: 1.08-3.62; likelihood ratio test (LRT) P-value: 0.01, n=203).

CONCLUSIONS

Dietary intake of acrylamide was not associated with overall or type-I EC risk; however, positive associations with type I were observed in women who were both non-users of OCs and never smokers.

摘要

背景

三项前瞻性研究评估了膳食丙烯酰胺摄入量与子宫内膜癌（EC）风险之间的关系，但结果不一致。本研究旨在评估丙烯酰胺摄入量与 EC 风险之间的关系：整体 EC、I 型 EC，以及从不吸烟者和从不使用口服避孕药（OCs）的女性中。吸烟是丙烯酰胺的来源，而 OC 使用是 EC 风险的保护因素。

方法

使用 Cox 回归估计丙烯酰胺摄入量与欧洲癌症前瞻性调查和营养研究（EPIC）队列中 EC 风险之间的关联的风险比（HR）。丙烯酰胺摄入量是从欧盟丙烯酰胺监测数据库中估算出来的，该数据库与基于 EPIC 问卷调查的食物消费数据相匹配。使用残差法对丙烯酰胺摄入量进行能量调整。

结果

丙烯酰胺摄入量与整体 EC（n=1382）或 I 型 EC 风险（n=627）之间没有关联。我们观察到，在从不吸烟且不使用 OCs 的女性中，I 型 EC 的相对风险随着丙烯酰胺摄入量的增加而增加（HRQ5vsQ1：1.97，95%CI：1.08-3.62；似然比检验（LRT）P 值：0.01，n=203）。

结论

膳食丙烯酰胺摄入量与整体或 I 型 EC 风险无关；然而，在从不使用 OCs 和从不吸烟的女性中，I 型 EC 与丙烯酰胺摄入量呈正相关。