Larsson Susanna C, Håkansson Niclas, Akesson Agneta, Wolk Alicja
Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Int J Cancer. 2009 Mar 1;124(5):1196-9. doi: 10.1002/ijc.24002.
Acrylamide has been found in foods heated at high temperatures and there is evidence of carcinogenicity of acrylamide in experimental animals. However, the potential health risks of dietary acrylamide intake in humans remain uncertain. We examined the association between dietary acrylamide intake and the incidence of endometrial cancer among 61,226 participants of the Swedish Mammography Cohort who were cancer-free at enrollment in 1987-1990 and completed a food frequency questionnaire at baseline and again in 1997. Cox proportional hazards models were used to estimate rate ratios with 95% confidence intervals, adjusted for endometrial cancer risk factors. During a mean follow-up of 17.7 years, a total of 687 incident cases of endometrial adenocarcinoma were diagnosed in the cohort. We found no association between long-term acrylamide intake and risk of endometrial cancer. The multivariate rate ratio of endometrial cancer for women in the highest quartile of acrylamide intake (mean, 33.8 microg/day) compared to those in the lowest quartile (mean, 15.9 microg/day) was 0.96 (95% CI, 0.76-1.21). The association did not vary materially by smoking status. In conclusion, these findings do not support the hypothesis that dietary acrylamide intake is positively associated with risk of endometrial cancer, at least not within the ranges of acrylamide consumed in this population.
在高温加热的食品中已发现丙烯酰胺，并且有证据表明丙烯酰胺在实验动物中具有致癌性。然而，人类通过饮食摄入丙烯酰胺的潜在健康风险仍不确定。我们在瑞典乳腺X线摄影队列研究的61226名参与者中，调查了饮食中丙烯酰胺摄入量与子宫内膜癌发病率之间的关联。这些参与者在1987 - 1990年入组时无癌症，并在基线时以及1997年再次完成了食物频率问卷调查。使用Cox比例风险模型来估计风险率比及其95%置信区间，并对子宫内膜癌风险因素进行了调整。在平均17.7年的随访期间，该队列中共诊断出687例子宫内膜腺癌病例。我们发现长期丙烯酰胺摄入量与子宫内膜癌风险之间没有关联。与丙烯酰胺摄入量最低四分位数组（平均每天15.9微克）的女性相比，摄入量最高四分位数组（平均每天33.8微克）的女性患子宫内膜癌的多变量风险率比为0.96（95%置信区间为0.76 - 1.21）。这种关联在吸烟状况方面没有实质性差异。总之，这些研究结果不支持饮食中丙烯酰胺摄入量与子宫内膜癌风险呈正相关的假设，至少在该人群所摄入的丙烯酰胺范围内不支持这一假设。
