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2
Is there an association between pemphigus and hepatitis viruses? A population-based large-scale study.天疱疮与肝炎病毒之间是否存在关联？一项基于人群的大规模研究。
Immunol Res. 2017 Oct;65(5):1083-1088. doi: 10.1007/s12026-017-8950-y.

本文引用的文献

1
Autoimmune bullous diseases the spectrum of infectious agent antibodies and review of the literature.自身免疫性大疱性疾病：病原体抗体谱及文献复习。
Autoimmun Rev. 2011 Jul;10(9):527-35. doi: 10.1016/j.autrev.2011.04.003. Epub 2011 Apr 16.
2
Autoimmune diseases co-existing with hepatitis C virus infection.与丙型肝炎病毒感染并存的自身免疫性疾病。
Iran J Allergy Asthma Immunol. 2010 Dec;9(4):191-206.
3
An uncommon presentation of the co-existence of morphea and vitiligo in a patient with chronic hepatitis B virus infection: is there a possible association with autoimmunity?一名慢性乙型肝炎病毒感染患者中硬斑病和白癜风共存的罕见表现：是否可能与自身免疫有关？
Am J Clin Dermatol. 2009;10(5):336-8. doi: 10.2165/11310800-000000000-00000.
4
Prevalence of hepatitis C serum antibody in autoimmune diseases.自身免疫性疾病中丙型肝炎血清抗体的患病率。
J Autoimmun. 2009 May-Jun;32(3-4):261-6. doi: 10.1016/j.jaut.2009.02.017. Epub 2009 Apr 8.
5
Pemphigus and infectious agents.天疱疮与感染因子。
Autoimmun Rev. 2008 Oct;8(1):33-5. doi: 10.1016/j.autrev.2008.07.021. Epub 2008 Aug 14.
6
Cutaneous manifestations in patients positive for anti-hepatitis C virus antibodies.
Acta Derm Venereol. 2007;87(1):49-53. doi: 10.2340/00015555-0186.
7
Infections and autoimmune diseases.感染与自身免疫性疾病。
J Autoimmun. 2005;25 Suppl:74-80. doi: 10.1016/j.jaut.2005.09.024. Epub 2005 Nov 8.
8
Hepatitis B virus-associated polyarteritis nodosa: clinical characteristics, outcome, and impact of treatment in 115 patients.乙型肝炎病毒相关性结节性多动脉炎：115例患者的临床特征、预后及治疗影响
Medicine (Baltimore). 2005 Sep;84(5):313-322. doi: 10.1097/01.md.0000180792.80212.5e.
9
Pemphigus following hepatitis B vaccination--coincidence or causality?
Autoimmunity. 2005 Mar;38(2):117-9. doi: 10.1080/08916930400027078.
10
Hepatitis B virus serologic markers and anti-hepatitis B vaccination in patients with diabetes.糖尿病患者的乙型肝炎病毒血清学标志物及乙型肝炎疫苗接种情况
Med Sci Monit. 2002 Jul;8(7):CR516-9.

丙型肝炎和乙型肝炎病毒感染在天疱疮发病机制中的作用

Hepatitis C and hepatitis B virus infections in the etiopathogenesis of pemphigus.

作者信息

Demirci Gulsen Tukenmez, Aydingoz Ikbal Esen, Mansur Ayse Tulin, Atis Guldehan, Altunay Ilknur Kivanc

机构信息

Istanbul Hospital, Faculty of Medicine, Baskent University, Istanbul, Turkey.

Faculty of Medicine, Acibadem University, Istanbul, Turkey.

出版信息

An Bras Dermatol. 2014 May-Jun;89(3):423-6. doi: 10.1590/abd1806-4841.20142566.

DOI:10.1590/abd1806-4841.20142566
PMID:24937815
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4056699/
Abstract

BACKGROUND

Previous studies have shown that some viral infections may be triggers for autoimmune diseases. The role of viral infections in the etiopathogenesis of pemphigus has also been investigated.

OBJECTIVES

To investigate the relationship between pemphigus and the hepatitis B and C virus infections.

METHODS

This retrospective study included 62 patients with pemphigus and 50 healthy controls of matching ages and genders. The control group included relatives who accompanied the orthopedic patients to the hospital but had no history of systemic and/or autoimmune diseases.

RESULTS

The group of patients with pemphigus was composed of 43 (69.3%) females and 19 (29.7%) males, and the mean age was 48.08 ± 15.38. The hepatitis C virus antibody was negative in all of the patients. Hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (HBsAb), or both, were studied in 44 of the 62 patients. Two (4.3%) of these patients were positive for HBsAg and found to have HBV infection. Fourteen of them were HBsAb positive. Two (4%) of the 50 control subjects showed hepatitis C virus antibody positivity, while only 1 (2%) patient with pemphigus displayed HBsAg positivity. There was no statistically significant difference between the two groups for hepatitis B and C virus infections.

CONCLUSIONS

This study does not support an association between pemphigus and hepatitis B and/or C virus infections.

摘要

背景

既往研究表明，某些病毒感染可能是自身免疫性疾病的触发因素。病毒感染在天疱疮发病机制中的作用也已得到研究。

目的

探讨天疱疮与乙型和丙型肝炎病毒感染之间的关系。

方法

这项回顾性研究纳入了62例天疱疮患者和50例年龄及性别匹配的健康对照者。对照组包括陪同骨科患者到医院但无全身和/或自身免疫性疾病病史的亲属。

结果

天疱疮患者组由43名（69.3%）女性和19名（29.7%）男性组成，平均年龄为48.08±15.38岁。所有患者的丙型肝炎病毒抗体均为阴性。62例患者中的44例研究了乙型肝炎表面抗原（HBsAg）、乙型肝炎表面抗体（HBsAb）或两者。其中2例（4.3%）患者HBsAg阳性，被发现感染了HBV。其中14例HBsAb阳性。50名对照者中有2例（4%）丙型肝炎病毒抗体阳性，而天疱疮患者中只有1例（2%）HBsAg阳性。两组在乙型和丙型肝炎病毒感染方面无统计学显著差异。

结论

本研究不支持天疱疮与乙型和/或丙型肝炎病毒感染之间存在关联。