Soylu Seçil, Gül Ulker, Gönül Müzeyyen, Kiliç Arzu, Cakmak Seray Külcü, Demiriz Murat
2nd Dermatology Clinic, Ankara Numune Education and Research Hospital, Sihhiye, Ankara, Turkey.
Am J Clin Dermatol. 2009;10(5):336-8. doi: 10.2165/11310800-000000000-00000.
A 30-year-old man presented with indurated violaceous plaques all over his body that had been present for 7 months. The patient had also had vitiligo for 3.5 years, and hepatitis B virus (HBV) infection and cirrhosis for a 2-year period. Histopathologic examination of the indurated plaques confirmed the diagnosis of morphea. Localized scleroderma and vitiligo have only rarely been reported to occur simultaneously. Although the etiologies of vitiligo and morphea are both uncertain, their association with autoimmune diseases favors an autoimmune hypothesis. Both vitiligo and morphea might have appeared coincidentally. However, this association could be significant because it may be related to the presence of HBV and alterations in the immune system that are caused by this virus. Therefore, this rare combination of vitiligo and morphea in a patient with chronic HBV infection warrants attention because it suggests a possible immunologic association, which may merit future study.
一名30岁男性全身出现硬结性紫罗兰色斑块7个月。该患者患白癜风3.5年，感染乙肝病毒（HBV）并患有肝硬化2年。硬结性斑块的组织病理学检查确诊为硬斑病。局限性硬皮病和白癜风同时发生的情况鲜有报道。虽然白癜风和硬斑病的病因均不明确，但它们与自身免疫性疾病的关联支持自身免疫假说。白癜风和硬斑病可能是巧合出现。然而，这种关联可能具有重要意义，因为它可能与HBV的存在以及该病毒引起的免疫系统改变有关。因此，慢性HBV感染患者中这种罕见的白癜风与硬斑病组合值得关注，因为它提示了一种可能的免疫关联，或许值得未来进一步研究。
