Zhou W K, Huang L Y, Hui L, Wang Z W, Jin B Z, Zhao X L, Zhang X Z, Wang J X, Wang J C, Wang R Z
Department of Neurosurgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
Department of Neurosurgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China
Genet Mol Res. 2014 May 16;13(2):3826-31. doi: 10.4238/2014.May.16.7.
We aimed to investigate the role of 4 single nucleotide polymorphisms of the xeroderma pigmentosum complementation group F (XPF) gene (rs3136038, rs1799798, rs1800067, and rs2276466) in glioma, and the roles of gene-gene interactions in the risk of developing this type of cancer. We collected samples from 225 glioma cases and 262 controls and genotyped the rs3136038, rs1799798, rs1800067, and rs2276466 polymorphisms using a 384-well plate format with the Sequenom MassARRAY platform. Individuals carrying the rs1800067 GG genotype were more likely to have an increased risk of glioma when compared with carriers of the A/A genotype in a co-dominant model, with an odds ratio (OR) [95% confidence interval (CI)] of 2.85 (1.14-7.76). However, we did not find an association with increased risk of glioma for the polymorphisms rs3136038, rs1799798, and rs2276466 in XPF. The combination genotype of the rs1800067 G allele and the rs2276466 G allele was associated with a moderate risk of glioma (OR = 1.71, 95%CI = 1.02-2.87). Our study suggests that the rs1800067 genetic variant of XPF functions in the development of glioma.
我们旨在研究着色性干皮病互补组F（XPF）基因的4个单核苷酸多态性（rs3136038、rs1799798、rs1800067和rs2276466）在胶质瘤中的作用，以及基因-基因相互作用在这种癌症发生风险中的作用。我们收集了225例胶质瘤病例和262例对照的样本，并使用Sequenom MassARRAY平台以384孔板形式对rs3136038、rs1799798、rs1800067和rs2276466多态性进行基因分型。在共显性模型中，与携带A/A基因型的个体相比，携带rs1800067 GG基因型的个体患胶质瘤的风险增加，优势比（OR）[95%置信区间（CI）]为2.85（1.14 - 7.76）。然而，我们未发现XPF基因中的rs3136038、rs1799798和rs2276466多态性与胶质瘤风险增加有关。rs1800067 G等位基因和rs2276466 G等位基因的组合基因型与中度胶质瘤风险相关（OR = 1.71，95%CI = 1.02 - 2.87）。我们的研究表明，XPF基因的rs1800067基因变异在胶质瘤的发生中起作用。
