Associations of mRNA expression of DNA repair genes and genetic polymorphisms with cancer risk: a bioinformatics analysis and meta-analysis.

A systematical bioinformatics and meta-analysis were carried out to establish our understanding of possible relationships between DNA repair genes and the development of cancer. The bioinformatics analysis confirmed that lower and levels and higher , , and levels were observed in 19 types of cancer, and subsequently results indicated that elevated and had a better impact on overall survival, however, higher , , and showed worse influence on cancer prognosis. The meta-analysis included 58 eligible studies demonstrated that harboring rs10817938, rs238406 increased overall cancer risk, however, rs2808668 SNP in overall cancer analysis and rs3136038 in the digestive system remarkably reduced the cancer risk. Moreover, no correlation was investigated for rs1870134, rs1346044 and rs1801195. These suggest that the DNA repair gene was associated with carcinogenesis, and contribute to the prognosis, and the critical SNPs further involved in affecting cancer risk.