Wu Huizhe, Li Shanqiong, Hu Xiaoyun, Qin Wenyan, Wang Yilin, Sun Tong, Wu Zhikun, Wang Xiufang, Lu Senxu, Xu Dongping, Li Yalun, Guan Shu, Zhao Haishan, Yao Weifan, Liu Mingyan, Wei Minjie
Department of Pharmacology, School of Pharmacy, Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation, China Medical University, Shenyang, 110122, P. R. China.
Department of Anorectal Surgery, First Hospital of China Medical University, Shenyang, 110001, P. R. China.
J Cancer. 2019 Jun 9;10(16):3593-3607. doi: 10.7150/jca.30975. eCollection 2019.
A systematical bioinformatics and meta-analysis were carried out to establish our understanding of possible relationships between DNA repair genes and the development of cancer. The bioinformatics analysis confirmed that lower and levels and higher , , and levels were observed in 19 types of cancer, and subsequently results indicated that elevated and had a better impact on overall survival, however, higher , , and showed worse influence on cancer prognosis. The meta-analysis included 58 eligible studies demonstrated that harboring rs10817938, rs238406 increased overall cancer risk, however, rs2808668 SNP in overall cancer analysis and rs3136038 in the digestive system remarkably reduced the cancer risk. Moreover, no correlation was investigated for rs1870134, rs1346044 and rs1801195. These suggest that the DNA repair gene was associated with carcinogenesis, and contribute to the prognosis, and the critical SNPs further involved in affecting cancer risk.
进行了系统的生物信息学和荟萃分析，以增进我们对DNA修复基因与癌症发生之间可能关系的理解。生物信息学分析证实，在19种癌症中观察到较低的[具体基因名称1]、[具体基因名称2]水平以及较高的[具体基因名称3]、[具体基因名称4]和[具体基因名称5]水平，随后的结果表明，升高的[具体基因名称3]和[具体基因名称4]对总生存期有较好影响，然而，较高的[具体基因名称1]、[具体基因名称2]和[具体基因名称5]对癌症预后显示出较差影响。荟萃分析纳入的58项合格研究表明，携带rs10817938、rs238406会增加总体癌症风险，然而，总体癌症分析中的rs2808668单核苷酸多态性以及消化系统中的rs3136038显著降低了癌症风险。此外，未对rs1870134、rs1346044和rs1801195进行相关性研究。这些表明DNA修复基因与致癌作用相关，并对预后有影响，关键的单核苷酸多态性进一步参与影响癌症风险。
