van Griensven G J, de Vroome E M, Goudsmit J, Coutinho R A
Department of Infectious Diseases, Municipal Health Service, Amsterdam, The Netherlands.
BMJ. 1989 Jan 28;298(6668):218-21. doi: 10.1136/bmj.298.6668.218.
To investigate the epidemiology and normal course of infection with HIV the prevalence and incidence of the infection were studied among two cohorts of homosexual men in Amsterdam in 1980-7. The cumulative incidence of infection increased from a weighted 2.2% in 1980 to 39.0% in 1987. The estimated yearly incidence of HIV was 3.0% in 1981, rose to 8.8% in 1984, and fell gradually to 0% in 1987. During the study the sexual behaviour of the cohorts was examined. The number of men with whom anopenetrative intercourse was practised fell from a mean of 10.6 to 1.4 for those positive for HIV antibody, whereas the number with whom anoreceptive intercourse was practised fell from a mean of 3.7 to 0.5 for those negative for the antibody. In addition, there was a reduction in the number of cases of hepatitis B and syphilis among men in general. The decline in infection with HIV was assumed to be linked to changes in sexual behaviour. Such changes practised early in the course of the epidemic probably had a strong effect on the number of cases of AIDS among homosexual men in Amsterdam.
为研究人类免疫缺陷病毒（HIV）感染的流行病学及自然病程，于1980 - 1987年对阿姆斯特丹两组男同性恋人群的HIV感染患病率及发病率进行了研究。感染的累积发病率从1980年加权后的2.2%增至1987年的39.0%。1981年HIV的估计年发病率为3.0%，1984年升至8.8%，并于1987年逐渐降至0%。在研究期间，对这两组人群的性行为进行了检查。对于HIV抗体呈阳性者，进行肛交的男性人数从平均10.6人降至1.4人，而对于抗体呈阴性者，进行肛交的男性人数从平均3.7人降至0.5人。此外，总体上男性中乙型肝炎和梅毒病例数也有所减少。HIV感染率的下降被认为与性行为的改变有关。在疫情早期出现的这种行为改变可能对阿姆斯特丹男同性恋者中的艾滋病病例数产生了重大影响。
