齐多夫定对无症状受试者血清人类免疫缺陷病毒抗原水平的影响。

Effect of zidovudine on serum human immunodeficiency virus antigen levels in symptom-free subjects.

作者信息

de Wolf F, Lange J M, Goudsmit J, Cload P, de Gans J, Schellekens P T, Coutinho R A, Fiddian A P, van der Noordaa J

机构信息

Department of Virology, University of Amsterdam, Netherlands.

出版信息

Lancet. 1988 Feb 20;1(8582):373-6. doi: 10.1016/s0140-6736(88)91179-8.

DOI:10.1016/s0140-6736(88)91179-8

PMID:2893187

Abstract

18 men with longstanding human immunodeficiency virus (HIV) antigenaemia but no symptoms received zidovudine in low-dose regimens (250 mg 6-hourly, 500 mg 6-hourly, or 500 mg 12-hourly) with or without acyclovir. Serum HIV antigen rose in only 1 patient and declined significantly in 13 (to below cut-off values in 9). In the 1 subject from whom HIV antigen positive cerebrospinal fluid was obtained, the fluid was antigen negative after 12 weeks of treatment. Acyclovir treatment alone or in addition did not seem to influence serum antigen levels. In 7 untreated men serum antigen levels rose or remained stable during follow-up. CD4+ cell counts increased in 14/18 treated subjects and 1/7 untreated subjects. No disease progression was observed in either group. Regression of enlarged lymph nodes was seen in the zidovudine-treated subjects. Adverse reactions to the study drugs were infrequent and mild. Anaemia caused symptoms in 2, but serious leucopenia or neutropenia was not observed.

摘要

18名患有长期人类免疫缺陷病毒（HIV）抗原血症但无症状的男性接受了低剂量齐多夫定治疗方案（每6小时250毫克、每6小时500毫克或每12小时500毫克），部分患者联合或不联合使用阿昔洛韦。仅1例患者血清HIV抗原升高，13例患者血清HIV抗原显著下降（9例降至临界值以下）。在1例获得HIV抗原阳性脑脊液的受试者中，治疗12周后脑脊液抗原转为阴性。单独使用阿昔洛韦或联合使用阿昔洛韦似乎均不影响血清抗原水平。7例未治疗的男性在随访期间血清抗原水平升高或保持稳定。14/18例接受治疗的受试者和1/7例未治疗的受试者CD4 + 细胞计数增加。两组均未观察到疾病进展。齐多夫定治疗的受试者出现肿大淋巴结消退。研究药物的不良反应罕见且轻微。2例患者因贫血出现症状，但未观察到严重白细胞减少或中性粒细胞减少。