Tan Jiao, Cheong Heesun, Park Yoon Shin, Kim Hangun, Zhang Meng, Moon Cheol, Huang Yongzhuo
College of Pharmacy, Sunchon National University, 255 Jungang-ro, Suncheon, Jeonnam 540- 950, Republic of Korea.
Curr Pharm Biotechnol. 2014;15(3):231-9. doi: 10.2174/1389201015666140617094320.
Biomacromolecules play an important role in the treatment of many diseases, but their topical application has been limited by their poor cell membrane permeability. Cell-penetrating peptides (CPPs) have been investigated over the past few decades as a potential strategy to overcome this challenge. CPPs can effectively mediate the cellular uptake of poorly internalized biomacromolecules without unfavorable side effects and have therefore attracted considerable interest as a viable alternative to existing parenteral therapies involving biomacromolecules. In this review, we will highlight the application of CPPs to the non-invasive delivery of biomacromolecules, with a focus on percutaneous and nasal absorption of biomacromolecules administered using CPPs.
生物大分子在多种疾病的治疗中发挥着重要作用，但其局部应用受到细胞膜通透性差的限制。在过去几十年中，人们一直在研究细胞穿透肽（CPPs），将其作为克服这一挑战的潜在策略。CPPs可以有效地介导内化能力差的生物大分子进入细胞，且无不良副作用，因此作为涉及生物大分子的现有肠胃外疗法的可行替代方案，引起了广泛关注。在本综述中，我们将重点介绍CPPs在生物大分子非侵入性递送中的应用，尤其关注使用CPPs给药的生物大分子的经皮和经鼻吸收。
