Baratzadeh Fatemeh, Butler Alexandra E, Kesharwani Prashant, Moallem Seyed Adel, Sahebkar Amirhossein
School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Clinical Pharmacy, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.
EXCLI J. 2022 Jun 22;21:840-851. doi: 10.17179/excli2022-4878. eCollection 2022.
Atherosclerosis is the most frequent cause of death globally. Oxidized low-density lipoprotein (ox-LDL) has an essential role in the formation of atherosclerotic plaques and foamy macrophages. Ox-LDL increases the uptake of cholesterol by macrophages and is the major cause of blood flow disruption. Ox-LDL is produced during oxidative stress and treatment with antioxidants could inhibit the production and function of ox-LDL. Curcumin is a potent antioxidant and has a strong track record in the treatment of numerous diseases. Recent studies indicate that Curcumin exerts a lipid-lowering effect, and can modulate the formation of atherosclerotic plaque. The current review focuses upon the role of Curcumin in oxidation of LDL and foam cell formation in atherosclerotic lesions.
动脉粥样硬化是全球最常见的死亡原因。氧化型低密度脂蛋白（ox-LDL）在动脉粥样硬化斑块和泡沫巨噬细胞的形成中起重要作用。ox-LDL增加巨噬细胞对胆固醇的摄取，是血流中断的主要原因。ox-LDL在氧化应激过程中产生，使用抗氧化剂治疗可抑制ox-LDL的产生和功能。姜黄素是一种有效的抗氧化剂，在治疗多种疾病方面有着良好的记录。最近的研究表明，姜黄素具有降脂作用，并可调节动脉粥样硬化斑块的形成。本综述重点关注姜黄素在动脉粥样硬化病变中低密度脂蛋白氧化和泡沫细胞形成中的作用。
