Zhang Jianfa, Tian Dongping, Lin Runhua, Zhou Guangzhao, Peng Guanyun, Su Min
First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, People's Republic of China.
1] Institute of Clinical Pathology & Department of Pathology, Shantou University Medical College, Shantou, Guangdong, People's Republic of China [2] The Judicial Critical Center, Shantou University Medical College, Shantou, Guangdong, People's Republic of China.
Sci Rep. 2014 Jun 18;4:5332. doi: 10.1038/srep05332.
The electron density resolution is 1000 times higher for synchrotron-radiation phase-contrast CT imaging than conventional X-ray absorption imaging in light elements, with which high-resolution X-ray imaging of biological soft tissue can be achieved. In the present study, we used phase-contrast X-ray CT to investigate human resected esophagus and esophageal carcinoma specimens. This technology revealed the three-layer structure of the esophageal wall-- mucous, submucosa and muscular layers. The mucous and muscular layers were clearly separated by a loose submucosa layer with a honeycomb appearance. The surface of the mucous layer was smooth. In esophageal carcinoma, because of tumor tissue infiltration, the submucosa layer was absent, which indicated destruction of the submucosa. The boundary between normal tissue and tumor was comparatively fuzzy, the three-layer structure of the esophageal wall was indistinct. The surface of the mucous layer was rugose. The technology might be helpful in tumor staging of esophageal carcinoma.
在轻元素中，同步辐射相衬CT成像的电子密度分辨率比传统X射线吸收成像高1000倍，利用这一点可以实现生物软组织的高分辨率X射线成像。在本研究中，我们使用相衬X射线CT对人切除的食管和食管癌标本进行研究。这项技术揭示了食管壁的三层结构——黏膜层、黏膜下层和肌层。黏膜层和肌层被具有蜂窝状外观的疏松黏膜下层清晰分隔。黏膜层表面光滑。在食管癌中，由于肿瘤组织浸润，黏膜下层缺失，这表明黏膜下层遭到破坏。正常组织与肿瘤之间的边界相对模糊，食管壁的三层结构不清晰。黏膜层表面粗糙。这项技术可能有助于食管癌的肿瘤分期。
