Bi Jia-Jia, Yi Li
Department of Neurology, Peking University Shenzhen Hospital, Shenzhen, 518036, China.
J Huazhong Univ Sci Technolog Med Sci. 2014 Jun;34(3):299-305. doi: 10.1007/s11596-014-1274-4. Epub 2014 Jun 18.
Integrins such as αvβ3, α5β1 play a key role in angiogenesis regulation, invasion and metastasis, inflammation, wound healing, etc. The up-regulation of integrin αvβ3 after cerebral ischemic stroke can promote angiogenesis, which in turn improves functional recovery. In addition, the integrin αvβ3 inhibitor can block the blood-brain barrier (BBB) leakage induced by vascular endothelial growth factor (VEGF) and also can reduce inflammatory reaction, decrease the deposition of fibrinogen. Other studies showed that integrin αvβ3 is not essential in revascularization. Therefore, the effect of integrin αvβ3 in the whole process of brain function recovery merits further study.
整合素如αvβ3、α5β1在血管生成调节、侵袭和转移、炎症、伤口愈合等过程中发挥关键作用。脑缺血性中风后整合素αvβ3的上调可促进血管生成，进而改善功能恢复。此外，整合素αvβ3抑制剂可阻断血管内皮生长因子（VEGF）诱导的血脑屏障（BBB）渗漏，还可减轻炎症反应，减少纤维蛋白原沉积。其他研究表明，整合素αvβ3在血管再生中并非必不可少。因此，整合素αvβ3在脑功能恢复全过程中的作用值得进一步研究。
