Zhou Da, Fang Ting, Lu Lin-Qing, Yi Li
Department of Neurology, Peking University Shenzhen Hospital, Shenzhen, 518036, China.
J Huazhong Univ Sci Technolog Med Sci. 2016 Aug;36(4):480-486. doi: 10.1007/s11596-016-1612-9. Epub 2016 Jul 28.
During the previous years, with the emerging of nanotechnology, the enormous capabilities of nanoparticles have drawn great attention from researchers in terms of their potentials in various aspects of pharmacology. Cerium oxide nanoparticles (nanoceria), considered as one of the most widely used nanomaterials, due to its tempting catalytic antioxidant properties, show a promising potential in diverse disorders, such as cerebral ischemic stroke (CIS), cancer, neurodegenerative and inflammatory diseases. Overwhelming generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) during cerebral ischemia and reperfusion periods is known to aggravate brain damage via sophisticated cellular and molecular mechanisms, and therefore exploration of the antioxidant capacities of nanoceria becomes a new approach in reducing cerebral ischemic injury. Furthermore, utilizing nanoceria as a drug carrier might display the propensity to overcome limitations or inefficacy of other conceivable neuroprotectants and exhibit synergistic effects. In this review, we emphasize on the principle features of nanoceria and current researches concerning nanoceria as a potential therapeutic agent or carrier in improving the prognosis of CIS.
在过去几年中，随着纳米技术的兴起，纳米颗粒的巨大能力因其在药理学各个方面的潜力而引起了研究人员的极大关注。氧化铈纳米颗粒（纳米氧化铈）被认为是使用最广泛的纳米材料之一，由于其诱人的催化抗氧化特性，在多种疾病中显示出有前景的潜力，如脑缺血性中风（CIS）、癌症、神经退行性疾病和炎症性疾病。已知在脑缺血和再灌注期间大量产生的活性氧（ROS）和活性氮（RNS）会通过复杂的细胞和分子机制加重脑损伤，因此探索纳米氧化铈的抗氧化能力成为减少脑缺血损伤的一种新方法。此外，将纳米氧化铈用作药物载体可能会显示出克服其他可设想的神经保护剂的局限性或无效性的倾向，并表现出协同效应。在这篇综述中，我们强调纳米氧化铈的主要特征以及目前关于纳米氧化铈作为改善CIS预后的潜在治疗剂或载体的研究。
