Department of Biochemistry, University of Madras, Guindy Campus, Chennai, 600 025, India.
J Biochem Mol Toxicol. 2014 Oct;28(10):442-9. doi: 10.1002/jbt.21583. Epub 2014 Jun 17.
Chronic hyperglycemia in diabetes is associated with profound changes in lipid and lipoprotein metabolism, with resultant alterations in particle distribution within lipoprotein classes. In the present study, an attempt has been made to explore the antihyperlipidemic effect of fisetin in streptozotocin-induced experimental diabetes in rats. Upon fisetin treatment to diabetic rats, the levels of blood glucose were significantly reduced with an improvement in plasma insulin. The increased levels of lipid contents in serum, hepatic, and renal tissues observed in diabetic rats were normalized upon fisetin administration. Also, the decreased levels of high-density lipoprotein cholesterol, and increased levels of low-density lipoprotein (LDL) and very LDL (VLDL) cholesterol in serum of diabetic rats were normalized. Oil Red O staining established a large number of intracellular lipid droplets accumulation in the diabetic rats. Fisetin treatment exacerbated the degree of lipid accumulation. The results of the present study exemplify the antihyperlipidemic property of the fisetin.
糖尿病患者的慢性高血糖与脂质和脂蛋白代谢的深刻变化有关，导致脂蛋白类中颗粒分布的改变。在本研究中，尝试探讨非瑟酮对链脲佐菌素诱导的实验性糖尿病大鼠的抗高血脂作用。非瑟酮治疗糖尿病大鼠后，血糖水平显著降低，血浆胰岛素水平得到改善。糖尿病大鼠血清、肝和肾组织中脂质含量升高的现象在非瑟酮给药后得到了正常化。此外，糖尿病大鼠血清中高密度脂蛋白胆固醇水平降低，低密度脂蛋白（LDL）和极低密度脂蛋白（VLDL）胆固醇水平升高的现象也得到了正常化。油红 O 染色显示糖尿病大鼠大量细胞内脂质滴的积累。非瑟酮处理加剧了脂质积累的程度。本研究的结果说明了非瑟酮的抗高血脂特性。
