Baba U A, Ashir G M, Mava Y, Gimba M S, Abubakar R, Ambe J P
Department of Paediatrics, Federal Medical Centre, Yola, Adamawa state, Nigeria; formerly, Department of Paediatrics University of Maiduguri Teaching Hospital (UMTH), Maiduguri, Borno state, Nigeria.
Department of Paediatrics, UMTH, Maiduguri, Borno state, Nigeria.
Afr Health Sci. 2013 Dec;13(4):940-6. doi: 10.4314/ahs.v13i4.12.
Maternal measles antibodies (MMA) are actively transferred through the placenta from mother to foetus. A relationship could exist between MMA of mother-infant pairs and maternal nutritional indicator (haemoglobin).
This study reviewed the effects of maternal haemoglobin (Hb) on MMA of mother-infant pairs at birth.
One hundred and fifty three mother-infant pairs were enrolled in this study using the systematic random sampling method. Means of maternal Hb and MMA of mother-infant pairs were compared using the Student t test. Correlation coefficients of maternal Hb and MMA of mother-infant pairs were also determined. Multivariate analysis of variable (MANOVA) and covariates (MANCOVA) was used to investigate the effects of maternal Hb (fixed factor), gestational age, maternal age, birth weight (covariates) on combined MMA of mother-infant pairs (dependent factors). Benferroni adjusted Univariate linear regression was used to investigate the dependent variables separately.
There were 78 (51%) males and 75 (49%) females. The (mean ± SD) MMA of mother-infant pairs at birth were 134.66 ± 93.31 (95% CI, 119.76 - 149.56) U/ml, and 187.49 ± 85.01 (95% CI, 173.91 - 201.07) U/ml, and their correlation was significant (p = 0.025). Ninety one (59.5 %) mothers had low Hb, 62 (40.5 %) had acceptable Hb levels. The overall mean maternal Hb was 11.01 ± 1.00 (95% CI, 10.85 - 11.17) g/dl . A positive significant correlation was observed between maternal Hb and MMA of the newborn-infant (p = 0.031). The MANOVA showed a statistically significant difference between maternal Hb on the combined dependent variables (p =0.033); however, results for the dependent variables using the Benferroni adjusted Univariate analysis was significant for only MMA of the infants, (p = 0.009).
There was a significant association between aacceptable levels of maternal Hb and high MMA of the newborn-infants. Therefore, these newborn infants start out with higher MMA that could give them better protection against measles during infancy.
母体麻疹抗体（MMA）通过胎盘从母亲主动转移至胎儿。母婴对的MMA与母体营养指标（血红蛋白）之间可能存在关联。
本研究回顾了母体血红蛋白（Hb）对出生时母婴对MMA的影响。
采用系统随机抽样方法招募了153对母婴。使用学生t检验比较母婴对的母体Hb和MMA的均值。还确定了母婴对的母体Hb和MMA的相关系数。使用多变量变量分析（MANOVA）和协变量分析（MANCOVA）来研究母体Hb（固定因素）、胎龄、母亲年龄、出生体重（协变量）对母婴对联合MMA（因变量）的影响。使用Bonferroni校正的单变量线性回归分别研究因变量。
有78名（51%）男性和75名（49%）女性。出生时母婴对的（均值±标准差）MMA分别为134.66±93.31（95%置信区间，119.76 - 149.56）U/ml和187.49±85.01（95%置信区间，173.91 - 201.07）U/ml，且它们的相关性显著（p = 0.025）。91名（59.5%）母亲的Hb水平较低，62名（40.5%）母亲的Hb水平可接受。母体Hb的总体均值为11.01±1.00（95%置信区间，10.85 - 11.17）g/dl。观察到母体Hb与新生儿的MMA之间存在显著正相关（p = 0.031）。MANOVA显示母体Hb对联合因变量有统计学显著差异（p = 0.033）；然而，使用Bonferroni校正的单变量分析得出的因变量结果仅对婴儿的MMA显著（p = 0.009）。
母体Hb的可接受水平与新生儿的高MMA之间存在显著关联。因此，这些新生儿出生时具有较高的MMA，这可以在婴儿期为他们提供更好的麻疹防护。
