Oyedele O Oluseyi, Odemuyiwa S O, Ammerlaan W, Muller C P, Adu F D
Department of Virology, College of Medicine, University of Ibadan.
J Trop Pediatr. 2005 Feb;51(1):45-8. doi: 10.1093/tropej/fmh073. Epub 2004 Dec 15.
Maternal and cord blood collected from 33 Nigerian mother-child pairs were tested for measles-sepcific IgG. All 33 had protective measles antibodies at the time of delivery with a positive correlation of r = 0.87. Determination of the rate of waning of these antibodies revealed that 58 per cent of these children had lost the protective maternal antibody by the age of 4 months and only 3 per cent of the children had enough antibody to protect them between the ages of 6-9 months. Fifty-five colostrum samples from the same mothers and 347 breastmilk samples collected at various periods of breastfeeding also showed that anti-measles IgA had dropped below the protective cut-off within the first 2 weeks of birth. It is evident that the Nigerian child is born with solid anti-measles antibody but the rate of waning has left a large number unprotected before the first dose of the vaccine. There is an urgent need to review the measles vaccination programme in Nigeria to protect these susceptible infants.
对从33对尼日利亚母婴采集的母血和脐带血进行了麻疹特异性IgG检测。所有33例在分娩时均具有保护性麻疹抗体，相关系数r = 0.87。对这些抗体衰减率的测定显示，58%的儿童在4月龄时已失去来自母亲的保护性抗体，只有3%的儿童在6 - 9月龄时有足够抗体保护自己。来自相同母亲的55份初乳样本以及在不同母乳喂养阶段采集的347份母乳样本也显示，抗麻疹IgA在出生后的头2周内已降至保护性临界值以下。显然，尼日利亚儿童出生时具有牢固的抗麻疹抗体，但抗体衰减率使大量儿童在接种第一剂疫苗之前未得到保护。迫切需要对尼日利亚的麻疹疫苗接种计划进行审查，以保护这些易感婴儿。
