Mizgirev I V, Maĭorova I G, Aleksandrov V A, Khudoleĭ V V
Eksp Onkol. 1989;11(1):21-4.
A well-known inductor of a system of multifunctional monooxygenases, the arochlor 1254, being applied to one-day rats produced an imprinting effect which was expressed in a strong and long-term increase in the metabolic activation of benzo(a)pyrene by the liver S9-fraction in the Salmonella/microsome test, as well as in the arylhydrocarbonhydroxylase activity. The imprinting was not revealed when the inductor was applied on the 9th day as well as it was not revealed for 2-acetylaminofluorene in the liver, or benzo(a)pyrene and 2-acetylaminofluorene in the kidneys, independently of the period of application.
一种著名的多功能单加氧酶系统诱导剂——多氯联苯混合物1254，应用于1日龄大鼠时会产生印记效应，表现为在沙门氏菌/微粒体试验中，肝脏S9组分对苯并(a)芘的代谢激活以及芳烃羟化酶活性出现强烈且长期的增加。当诱导剂在第9天应用时未发现印记效应，并且无论应用时期如何，对于肝脏中的2-乙酰氨基芴，或肾脏中的苯并(a)芘和2-乙酰氨基芴，均未发现印记效应。
