Kholoud S R, Iman M K A, Rasha E H, Soha S S A
Department of Biochemistry, Faculty of Girls Science, King Abdulaziz University, Jeddah, Saudi Arabia ; Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
Department of hydrobiology, National Research Center, Cairo, Egypt.
Afr Health Sci. 2013 Dec;13(4):1062-70. doi: 10.4314/ahs.v13i4.29.
Myocarditis is an uncommon disease that presents with a wide range of symptoms in children and adults. It is histologically characterized by varying degrees of myocardialnecrosis, edema and cellular infiltration myocardial inflammation is a nonspecificresponse to many triggers such as bacterial infection, cardio toxic agents, ormechanical injury.
This study was carried out to investigate the experimental Streptococcus faecalis induction of myocarditis and its effect on some blood parameters, inflammatory markers and histopathological changes in male albino rats.
Rats were infected by intraperitoneal injection of 10 8 CFU/ml of Streptococcus faecalis and sacrificed after one, two and seven days post infection. Biochemical analyses of blood were carried out to investigate the serum biomarkers of inflammation, liver function tests, cardiac enzymes & kidney function tests.
All biochemical analyses showed statistically significant increase in the measured parameters due to bacterial infections except for blood urea which appear to be normal. A significant positive correlation was observed between lactate dehydrogenase enzyme (LDH) with creatinine (r =0.778, P<0.01). In the 7 days group, there were significant positive correlations between aspartate aminotransferase (AST) and alanine aminotransferase (ALT) (r=0.675, P<0.05), erythrocyte sedimentation rate (ESR) with Urea (r=0.659, P<0.05) and alkaline phosphatase (ALP) with C-reactive protein (CRP) (r=0.765, p<0.01).
Many of these biomarkers will provide important new insights into pathophysiology and aid in the diagnosis and management of cardiovascular patients.
心肌炎是一种罕见疾病，在儿童和成人中症状表现多样。其组织学特征为不同程度的心肌坏死、水肿和细胞浸润。心肌炎症是对许多触发因素的非特异性反应，如细菌感染、心脏毒性药物或机械损伤。
本研究旨在探讨粪肠球菌诱导实验性心肌炎及其对雄性白化大鼠某些血液参数、炎症标志物和组织病理学变化的影响。
通过腹腔注射10⁸CFU/ml粪肠球菌感染大鼠，并在感染后1天、2天和7天处死。进行血液生化分析以研究炎症血清生物标志物、肝功能测试、心脏酶和肾功能测试。
除血尿素似乎正常外，所有生化分析均显示由于细菌感染，测量参数有统计学意义的增加。乳酸脱氢酶（LDH）与肌酐之间观察到显著正相关（r = 0.778，P<0.01）。在7天组中，天冬氨酸转氨酶（AST）与丙氨酸转氨酶（ALT）之间存在显著正相关（r = 0.675，P<0.05），红细胞沉降率（ESR）与尿素之间存在显著正相关（r = 0.659，P<0.05），碱性磷酸酶（ALP）与C反应蛋白（CRP）之间存在显著正相关（r = 0.765，p<0.01）。
许多这些生物标志物将为病理生理学提供重要的新见解，并有助于心血管疾病患者的诊断和管理。
