Guo Changlei, Zhang Shaoli, Zhang Junbiao, Liu Hui, Li Peicheng, Liu Hengdao, Wang Yakun
Department of Cardiovascular Internal Medicine, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan 453100, P.R. China.
Exp Ther Med. 2014 May;7(5):1177-1180. doi: 10.3892/etm.2014.1565. Epub 2014 Feb 20.
The aim of this study was to investigate the correlation between the severity of coronary artery lesions in patients with acute coronary syndromes (ACS) and levels of estrogen, high-sensitivity C-reactive protein (hs-CRP) and matrix metalloproteinase-9 (MMP-9). A total of 65 patients with ACS, 33 patients with stable angina pectoris (SAP) and 36 healthy controls were randomly enrolled. Patients with ACS were subdivided into two groups: Acute myocardial infarction (AMI; n=30) and unstable angina pectoris (UAP; n=35). Serum levels of estrogen, hs-CRP and MMP-9 were detected in the four groups of subjects. Serum estrogen levels in patients with AMI, UAP and SAP were significantly lower than those in the control group (P<0.05). Estrogen levels were also significantly different among the AMI, UAP and SAP groups (P<0.05), with a progressive increase across the three respective groups. Compared with healthy subjects, patients with AMI had the highest levels of hs-CRP and MMP-9, followed in descending order by those with UAP and SAP (P<0.05). Levels of hs-CRP and MMP-9 were also significantly different among the AMI, UAP and SAP groups (P<0.05). Serum estrogen levels were negatively correlated with hs-CRP and MMP-9 levels (r=-0.6634 and -0.6878, respectively; both P<0.05). hs-CRP and MMP-9 levels correlated positively (r=0.7208, P<0.05). The number of stenosed coronary vessels was negatively correlated with estrogen levels (r=-0.6467, P<0.05), and positively correlated with hs-CRP and MMP-9 levels (r=0.6519 and 0.6835, respectively; both P<0.05). In conclusion, serum estrogen, hs-CRP and MMP-9 levels were significantly correlated with the severity of coronary artery lesions. There was also a significant correlation between serum estrogen, hs-CRP and MMP-9 levels. These data indicate that serum estrogen, hs-CRP and MMP-9 have the potential to be used as biomarkers for evaluating the severity of coronary artery lesions and the stability of coronary artery plaques.
本研究旨在探讨急性冠状动脉综合征（ACS）患者冠状动脉病变严重程度与雌激素、高敏C反应蛋白（hs-CRP）及基质金属蛋白酶-9（MMP-9）水平之间的相关性。共随机纳入65例ACS患者、33例稳定型心绞痛（SAP）患者及36例健康对照者。ACS患者被分为两组：急性心肌梗死（AMI；n = 30）和不稳定型心绞痛（UAP；n = 35）。检测四组受试者血清中雌激素、hs-CRP和MMP-9水平。AMI、UAP和SAP患者的血清雌激素水平显著低于对照组（P<0.05）。AMI、UAP和SAP组之间的雌激素水平也存在显著差异（P<0.05），且在三组中呈逐渐升高趋势。与健康受试者相比，AMI患者的hs-CRP和MMP-9水平最高，其次依次为UAP和SAP患者（P<0.05）。AMI、UAP和SAP组之间的hs-CRP和MMP-9水平也存在显著差异（P<0.05）。血清雌激素水平与hs-CRP和MMP-9水平呈负相关（r分别为-0.6634和-0.6878；均P<0.05）。hs-CRP和MMP-9水平呈正相关（r = 0.7208，P<0.05）。冠状动脉狭窄血管数量与雌激素水平呈负相关（r = -0.6467，P<0.05），与hs-CRP和MMP-9水平呈正相关（r分别为0.6519和0.6835；均P<0.05）。综上所述，血清雌激素、hs-CRP和MMP-9水平与冠状动脉病变严重程度显著相关。血清雌激素、hs-CRP和MMP-9水平之间也存在显著相关性。这些数据表明，血清雌激素、hs-CRP和MMP-9有可能作为评估冠状动脉病变严重程度和冠状动脉斑块稳定性的生物标志物。
