Jiang Youhua, Ni Kewei, Fang Meiyu, Li Junling
Department of Thoracic Surgery, Zhejiang Cancer Hospital, Hangzhou 310000, P.R. China.
Department of Cardio-Thoracic Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310000, P.R. China.
Iran J Public Health. 2019 Jul;48(7):1265-1269.
This study intended to investigate the effects of serum high-sensitivity C-reactive protein (hs-CRP) on the incidence of lung cancer in male patients with pulmonary tuberculosis.
A total of 1091 male patients with pulmonary tuberculosis in Zhejiang Cancer Hospital, Hangzhou, China from Jan 2009 to Jan 2012 were selected as the research objects. All patients were followed up from the beginning of hospitalization. According to serum hs-CRP level, patients were divided into two groups: group A (hs-CRP < 1 mg/L) and group B (hs-CRP > 3 mg/L). The relationship between baseline hs-CRP and the risk of lung cancer in patients with pulmonary tuberculosis was analyzed by multivariate Cox proportional risk regression model, and the serum levels of hs-CRP between lung cancer patients in all groups and other non-lung cancer patients were compared.
There were differences in age, drinking, smoking, diabetes history, body mass index (BMI), thyroglobulin (TG), history of hypertension and hyperglycemia among the three groups (=0.036, 0.018, 0.040, 0.029, 0.006, 0.034, 0.020, 0.010). The serum levels of hs-CRP in patients with squamous carcinoma, adenocarcinoma and small cell carcinoma were significantly higher than those in non-lung cancer patients (=0.022, 0.043, 0.011). The incidence rates of lung cancer in patients in group B and C were 1.37 and 1.69 times higher than that in group A, respectively.
The increased serum level of hs-CRP will increase the incidence rate of lung cancer in male patients with pulmonary tuberculosis.
本研究旨在探讨血清高敏C反应蛋白（hs-CRP）对男性肺结核患者肺癌发生率的影响。
选取2009年1月至2012年1月在中国杭州浙江省肿瘤医院就诊的1091例男性肺结核患者作为研究对象。所有患者自住院起开始随访。根据血清hs-CRP水平，将患者分为两组：A组（hs-CRP<1mg/L）和B组（hs-CRP>3mg/L）。采用多因素Cox比例风险回归模型分析肺结核患者基线hs-CRP与肺癌风险的关系，并比较各组肺癌患者与其他非肺癌患者的血清hs-CRP水平。
三组患者在年龄、饮酒、吸烟、糖尿病史、体重指数（BMI）、甲状腺球蛋白（TG）、高血压病史和高血糖病史方面存在差异（P=0.036、0.018、0.040、0.029、0.006、0.034、0.020、0.010）。鳞癌、腺癌和小细胞癌患者的血清hs-CRP水平显著高于非肺癌患者（P=0.022、0.043、0.011）。B组和C组患者的肺癌发生率分别比A组高1.37倍和1.69倍。
血清hs-CRP水平升高会增加男性肺结核患者的肺癌发生率。
