非晶态和晶态硫化镍对α/β干扰素、γ干扰素及白细胞介素-2诱导的影响。

Effects of amorphous and crystalline nickel sulfide on induction of interferons-alpha/beta and -gamma and interleukin-2.

作者信息

Jaramillo A, Sonnenfeld G

机构信息

Department of Microbiology and Immunology, School of Medicine, University of Louisville, Kentucky 40292.

出版信息

Environ Res. 1989 Apr;48(2):275-86. doi: 10.1016/s0013-9351(89)80040-4.

DOI:10.1016/s0013-9351(89)80040-4

PMID:2494047

Abstract

Pretreatment of rat spleen cells with crystalline or amorphous nickel sulfide (NiS) did not inhibit induction of interferon-gamma or interleukin-2 by concanavalin A. In contrast, pretreatment of murine L-929 cells with crystalline NiS inhibited severely IFN-alpha/beta induction by polyriboinosinic-polyribocytidylic acid, while amorphous NiS did not show any effect. This difference in the effects of both forms of NiS on the spleen and L-929 cells correlated with the cellular internalization of the compound; L-929 cells actively phagocytosed crystalline NiS while the uptake of amorphous NiS by the same type of cells was minimal. The uptake of both crystalline and amorphous NiS by spleen cells was very low.

摘要

用结晶或无定形硫化镍（NiS）预处理大鼠脾细胞，不会抑制伴刀豆球蛋白A诱导的γ干扰素或白细胞介素-2。相反，用结晶NiS预处理小鼠L-929细胞，会严重抑制聚肌苷酸-聚胞苷酸诱导的IFN-α/β，而无定形NiS则没有任何作用。两种形式的NiS对脾细胞和L-929细胞作用的这种差异与化合物的细胞内化相关；L-929细胞主动吞噬结晶NiS，而同一类型细胞对无定形NiS的摄取极少。脾细胞对结晶和无定形NiS的摄取都非常低。