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用于检测葡萄糖浓度和指示脱水水平的改进型非接触式光学传感器。

Improved noncontact optical sensor for detection of glucose concentration and indication of dehydration level.

作者信息

Ozana Nisan, Arbel Nadav, Beiderman Yevgeny, Mico Vicente, Sanz Martin, Garcia Javier, Anand Arun, Javidi Baharam, Epstein Yoram, Zalevsky Zeev

机构信息

Faculty of Engineering, Bar-Ilan University, Ramat-Gan 52900, Israel.

Departamento de Óptica, Universitat de València, c/Dr. Moliner, 50, 46100 Burjassot, Spain.

出版信息

Biomed Opt Express. 2014 May 22;5(6):1926-40. doi: 10.1364/BOE.5.001926. eCollection 2014 Jun 1.

DOI:10.1364/BOE.5.001926
PMID:24940550
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4052851/
Abstract

The ability to extract different bio-medical parameters from one single wristwatch device can be very applicable. The wearable device that is presented in this paper is based on two optical approaches. The first is the extraction and separation of remote vibration sources and the second is the rotation of linearly polarized light by certain materials exposed to magnetic fields. The technique is based on tracking of temporal changes of reflected secondary speckles produced in the wrist when being illuminated by a laser beam. Change in skin's temporal vibration profile together with change in the magnetic medium that is generated by time varied glucose concentration caused these temporal changes. In this paper we present experimental tests which are the first step towards an in vivo noncontact device for detection of glucose concentration in blood. The paper also shows very preliminary results for qualitative capability for indication of dehydration.

摘要

从单个手表设备中提取不同生物医学参数的能力可能非常适用。本文介绍的可穿戴设备基于两种光学方法。第一种是远程振动源的提取和分离,第二种是某些材料在磁场作用下使线偏振光发生旋转。该技术基于对激光束照射手腕时产生的反射二次散斑的时间变化进行跟踪。皮肤时间振动轮廓的变化以及由随时间变化的葡萄糖浓度产生的磁介质变化导致了这些时间变化。在本文中,我们展示了实验测试,这是迈向用于检测血液中葡萄糖浓度的体内非接触式设备的第一步。本文还展示了关于脱水指示定性能力的非常初步的结果。

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本文引用的文献

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Demonstration of remote optical measurement configuration that correlates to glucose concentration in blood.与血液中葡萄糖浓度相关的远程光学测量配置的演示。
Biomed Opt Express. 2011 Mar 14;2(4):858-70. doi: 10.1364/BOE.2.000858.
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Remote estimation of blood pulse pressure via temporal tracking of reflected secondary speckles pattern.通过对反射二次散斑图案的时间跟踪来远程估计血压脉搏压。
J Biomed Opt. 2010 Nov-Dec;15(6):061707. doi: 10.1117/1.3505008.
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J Diabetes Sci Technol. 2009 Mar 1;3(2):253-60. doi: 10.1177/193229680900300205.
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Simultaneous remote extraction of multiple speech sources and heart beats from secondary speckles pattern.从二次散斑图案中同时远程提取多个语音源和心跳信号。
Opt Express. 2009 Nov 23;17(24):21566-80. doi: 10.1364/OE.17.021566.
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Polarization-based diffuse reflectance imaging for noninvasive measurement of glucose.基于偏振的漫反射成像用于葡萄糖的无创测量。
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