含ras逆转录病毒对人肾近端小管细胞的转化。对肿瘤进展的影响。
Transformation of human kidney proximal tubule cells by ras-containing retroviruses. Implications for tumor progression.
作者信息
Nanus D M, Ebrahim S A, Bander N H, Real F X, Pfeffer L M, Shapiro J R, Albino A P
机构信息
Memorial Sloan-Kettering Cancer Center, New York, New York.
出版信息
J Exp Med. 1989 Mar 1;169(3):953-72. doi: 10.1084/jem.169.3.953.
Abstract
Normal human kidney proximal tubule cells into which a ras oncogene was inserted undergo a series of transformation-related alterations that are characteristic of renal carcinomas. These include changes in morphology, growth potential, anchorage dependence, antigen expression, growth factor production, and chromosomal stability. Further, there are spontaneous progressive alterations in vitro in the karyotype and antigenic profile of the transformed cells. Cytogenetic analyses suggest that alterations of chromosome 21 may play an early and pivotal role in the development of transformed proximal tubule cells.
摘要
导入了ras癌基因的正常人类肾近端小管细胞会经历一系列与转化相关的改变，这些改变是肾癌的特征。这些改变包括形态、生长潜能、贴壁依赖性、抗原表达、生长因子产生和染色体稳定性的变化。此外，转化细胞的核型和抗原谱在体外会发生自发的渐进性改变。细胞遗传学分析表明，21号染色体的改变可能在转化的近端小管细胞的发展中起早期关键作用。
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